Evidence map›Paper›PMID 28228269›Full record

ArticleCell reports2017

Diverse Central Projection Patterns of Retinal Ganglion Cells.

Emily M Martersteck, Karla E Hirokawa, Mariah Evarts, Amy Bernard, Xin Duan, Yang Li, Lydia Ng, Seung W Oh, Benjamin Ouellette, Joshua J Royall and 5 more

Abstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed.

  1. Article
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  10. Recovery of Retinal Terminal Fields after Traumatic Brain Injury: Evidence of Collateral Sprouting and Sexual Dimorphism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  11. Absence of local retinotopy in the mouse optic tract.Frontiers in neural circuits · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Emily M MartersteckCenter for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Karla E HirokawaAllen Institute for Brain Science, Seattle, WA 98109, USA.
Mariah EvartsCenter for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Amy BernardAllen Institute for Brain Science, Seattle, WA 98109, USA.
Xin DuanCenter for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Yang LiAllen Institute for Brain Science, Seattle, WA 98109, USA.
Lydia NgAllen Institute for Brain Science, Seattle, WA 98109, USA.
Seung W OhAllen Institute for Brain Science, Seattle, WA 98109, USA.
Benjamin OuelletteAllen Institute for Brain Science, Seattle, WA 98109, USA.
Joshua J RoyallAllen Institute for Brain Science, Seattle, WA 98109, USA.
Michelle StoecklinAllen Institute for Brain Science, Seattle, WA 98109, USA.
Quanxin WangAllen Institute for Brain Science, Seattle, WA 98109, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA 98109, USA.
Joshua R SanesCenter for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: sanesj@mcb.harvard.edu.
Julie A HarrisAllen Institute for Brain Science, Seattle, WA 98109, USA. Electronic address: julieha@alleninstitute.org.

Funding

Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Gabriel Kreiman · 1998 to 2026
$21.3M
Synaptic Choices in the Retinotectal SystemR01NS029169 · NINDS · WASHINGTON UNIVERSITY · PI SANES, JOSHUA R · 1991 to 2012
$6.0M
Comprehensive Classification Of Neuronal Subtypes By Single Cell TranscriptomicsU01MH105960 · NIMH · HARVARD UNIVERSITY · PI REGEV, AVIV, SANES, JOSHUA R · 2014 to 2016
$4.5M
Synaptic Choices in the Retinotectal SystemR37NS029169 · NINDS · HARVARD UNIVERSITY · PI SANES, JOSHUA R · 2013 to 2019
$4.0M
Combinatorial roles of cadherins in retinal circuit assembly.R01EY022073 · NEI · HARVARD UNIVERSITY · PI SANES, JOSHUA R · 2012 to 2020
$3.7M
NEI NIH HHS P30 EY012196NEI NIH HHS R01 EY022073NIMH NIH HHS U01 MH105960NINDS NIH HHS R01 NS029169NINDS NIH HHS R37 NS029169
6 · The paper itself

Abstract

Understanding how >30 types of retinal ganglion cells (RGCs) in the mouse retina each contribute to visual processing in the brain will require more tools that label and manipulate specific RGCs. We screened and analyzed retinal expression of Cre recombinase using 88 transgenic driver lines. In many lines, Cre was expressed in multiple RGC types and retinal cell classes, but several exhibited more selective expression. We comprehensively mapped central projections from RGCs labeled in 26 Cre lines using viral tracers, high-throughput imaging, and a data processing pipeline. We identified over 50 retinorecipient regions and present a quantitative retina-to-brain connectivity map, enabling comparisons of target-specificity across lines. Projections to two major central targets were notably correlated: RGCs projecting to the outer shell or core regions of the lateral geniculate projected to superficial or deep layers within the superior colliculus, respectively. Retinal images and projection data are available online at http://connectivity.brain-map.org.

Indexed as

AnimalsIntegrasesMiceMice, TransgenicRetinaRetinal Ganglion CellsSuperior ColliculiVisual PathwaysCre recombinaseIntegrasesaxon projectionsconnectivity mappingCre driverretinal ganglion cell types

Identifiers

PMID28228269
PMCPMC5357325

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.