Evidence map›Paper›PMID 28228261›Full record

ArticleCell reports2017

Context-Dependent Effects of Amplified MAPK Signaling during Lung Adenocarcinoma Initiation and Progression.

Michelle Cicchini, Elizabeth L Buza, Kyra M Sagal, A Andrea Gudiel, Amy C Durham, David M Feldser

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Multifaceted role for p53 in pancreatic cancer suppression.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michelle CicchiniDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, BRBII/III, Philadelphia, PA 19104, USA.
Elizabeth L BuzaDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Rosenthal Bldg., Philadelphia, PA 19104, USA.
Kyra M SagalDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, BRBII/III, Philadelphia, PA 19104, USA.
A Andrea GudielDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, BRBII/III, Philadelphia, PA 19104, USA.
Amy C DurhamDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Rosenthal Bldg., Philadelphia, PA 19104, USA.
David M FeldserDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, BRBII/III, Philadelphia, PA 19104, USA. Electronic address: dfeldser@upenn.edu.
University of Pennsylvania · USCancer Research Institute · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Translational Research Training Program in Environmental Health SciencesT32ES019851 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Kara A Bernstein, Trevor M Penning · 2012 to 2026
$6.0M
p53-Mediated Tumor Immune SurveillanceR01CA193602 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FELDSER, DAVID · 2015 to 2019
$2.0M
Establishing therapeutic efficacy and uncovering mechanisms of tumor suppressionR00CA158581 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FELDSER, DAVID · 2013 to 2015
$707k
Identifying Mechanisms of p53 and Rb Tumor Suppression In Small Cell Lung CancerR21CA205340 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FELDSER, DAVID · 2016 to 2017
$385k
NCI NIH HHS P30 CA016520NCI NIH HHS R00 CA158581NCI NIH HHS R01 CA193602NCI NIH HHS R21 CA205340NIEHS NIH HHS P30 ES013508NIEHS NIH HHS T32 ES019851
6 · The paper itself

Abstract

Expression of oncogenic Kras

Indexed as

AdenocarcinomaAdenocarcinoma of LungAnimalsCarcinogenesisCell ProliferationCell Transformation, NeoplasticDisease ProgressionLung NeoplasmsMAP Kinase Signaling SystemMiceMitogen-Activated Protein KinasesProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Signal TransductionMitogen-Activated Protein KinasesProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Kraslung adenocarcinomaMAPKp53

Identifiers

PMID28228261
PMCPMC5405440
OpenAlexW2590140826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.