Evidence map›Paper›PMID 28228257›Full record

ArticleCell reports2017

T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow.

Arielle Glatman Zaretsky, Christoph Konradt, Fabien Dépis, James B Wing, Radhika Goenka, Daniela Gomez Atria, Jonathan S Silver, Sunglim Cho, Amaya I Wolf, William J Quinn and 10 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Why are long-lived plasma cells long-lived?Frontiers in immunology · 2026
    Review
  7. IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
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  14. Review
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  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Arielle Glatman ZaretskySchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christoph KonradtSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Fabien DépisDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
James B WingLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan.
Radhika GoenkaPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Daniela Gomez AtriaPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jonathan S SilverSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sunglim ChoDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Amaya I WolfThe Wistar Institute, Philadelphia, PA 19104, USA.
William J QuinnPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Julie B EngilesSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dorothy C BrownSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Daniel BeitingSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jan EriksonThe Wistar Institute, Philadelphia, PA 19104, USA.
David AllmanPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael P CancroPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Shimon SakaguchiLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan.
Li-Fan LuDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Christophe O BenoistDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Christopher A HunterSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: chunter@vet.upenn.edu.
University of Pennsylvania · USHarvard University · USOsaka University · JPThe Wistar Institute · USUniversity of California, San Diego · US

Funding

PARASITOLOGY: MODERN APPROACHEST32AI007532 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 1998 to 2022
$5.0M
IMMUNOPATHOGENESIS OF TOXOPLASMIC ENCEPHALITISR01AI041158 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 1996 to 2019
$4.8M
Training in Emerging Infectious DiseasesT32AI055400 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA, HENSLEY, SCOTT ERIC · 2003 to 2022
$4.4M
Immune System Development and RegulationT32AI055428 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M, OLIVER, PAULA MARIA · 2003 to 2025
$4.2M
Naive T cell homeostasis: Treg selection and survivalR37AI051530 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2009 to 2018
$4.1M
Role of microRNAs in regulatory T cell-mediated immunological tolerance and T celR01AI108651 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2014 to 2024
$4.0M
Naive T cell survival: TCR and IL-7R signal interplayR01AI051530 · NIAID · JOSLIN DIABETES CENTER · PI BENOIST, CHRISTOPHE O. · 2002 to 2009
$2.4M
IL-27 and Treg cellsR01AI110201 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2014 to 2018
$2.0M
Long-lived CD19-positive plasma cellsR01AI097590 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M · 2012 to 2016
$1.9M
FLIM system, resonant scanner, and UV laser for 2 photon microscopeS10RR027128 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2010 to 2010
$496k
Role of miR-146a at the interface between T and B cell immunityR21AI123782 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2016 to 2017
$420k
NCRR NIH HHS S10 RR027128NIAID NIH HHS R01 AI041158NIAID NIH HHS R01 AI051530NIAID NIH HHS R01 AI097590NIAID NIH HHS R01 AI108651NIAID NIH HHS R01 AI110201NIAID NIH HHS R21 AI123782NIAID NIH HHS R37 AI051530NIAID NIH HHS T32 AI007532NIAID NIH HHS T32 AI055400NIAID NIH HHS T32 AI055428
6 · The paper itself

Abstract

Long-lived plasma cells (PCs) in the bone marrow (BM) are a critical source of antibodies after infection or vaccination, but questions remain about the factors that control PCs. We found that systemic infection alters the BM, greatly reducing PCs and regulatory T (Treg) cells, a population that contributes to immune privilege in the BM. The use of intravital imaging revealed that BM Treg cells display a distinct behavior characterized by sustained co-localization with PCs and CD11c-YFP

Indexed as

AnimalsAutoimmunityBone MarrowBone Marrow CellsCTLA-4 AntigenImmunity, HumoralImmunophenotypingMiceMice, Inbred C57BLPlasma CellsT-Lymphocytes, RegulatoryCTLA-4 AntigenantibodyB cellsbone marrowinfectious diseaseplasma cellT regulatory cell

Identifiers

PMID28228257
PMCPMC5361408
OpenAlexW2591123228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.