Evidence map›Paper›PMID 28228132›Full record

SynthesisBMC medical informatics and decision making2017

Information needs for making clinical recommendations about potential drug-drug interactions: a synthesis of literature review and interviews.

Katrina M Romagnoli, Scott D Nelson, Lisa Hines, Philip Empey, Richard D Boyce, Harry Hochheiser

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in BMC medical informatics and decision making, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  4. Article
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  6. Article
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  12. Article
  13. Drug interaction screening in SWOG clinical trials.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2018
    Article
  14. Drug-drug Interaction-related Uncontrolled Glycemia.Journal of pharmacy & bioallied sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katrina M RomagnoliDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Scott D NelsonDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Lisa HinesPharmacy Quality Alliance, Springfield, VA, USA.
Philip EmpeySchool of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA, USA.
Richard D BoyceDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Harry HochheiserDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA. harryh@pitt.edu.ORCID 0000-0001-8793-9982

Funding

The internship in Biomedical Research, Informatics, and Computer Science (iBRIC): Biomedical Informatics and Data Science research experiences for students from Minority Serving InstitutionsT15LM007059 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRY S HOCHHEISER · 1987 to 2026
$23.9M
The University of Pittsburgh's Comparative Effectiveness Research Scholars PrograK12HS019461 · AHRQ · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAPOOR, WISHWA N · 2010 to 2010
$1.9M
Addressing gaps in clinically useful evidence on drug-drug interactionsR01LM011838 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYCE, RICHARD DAVID · 2014 to 2017
$1.6M
Improving medication safety for nursing home residents prescribed psychotropic drK01AG044433 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYCE, RICHARD DAVID · 2014 to 2016
$342k
AHRQ HHS K12 HS019461NIA NIH HHS K01 AG044433NLM NIH HHS R01 LM011838NLM NIH HHS T15 LM007059
6 · The paper itself

Abstract

backgroundDrug information compendia and drug-drug interaction information databases are critical resources for clinicians and pharmacists working to avoid adverse events due to exposure to potential drug-drug interactions (PDDIs). Our goal is to develop information models, annotated data, and search tools that will facilitate the interpretation of PDDI information. To better understand the information needs and work practices of specialists who search and synthesize PDDI evidence for drug information resources, we conducted an inquiry that combined a thematic analysis of published literature with unstructured interviews.

methodsStarting from an initial set of relevant articles, we developed search terms and conducted a literature search. Two reviewers conducted a thematic analysis of included articles. Unstructured interviews with drug information experts were conducted and similarly coded. Information needs, work processes, and indicators of potential strengths and weaknesses of information systems were identified.

resultsReview of 92 papers and 10 interviews identified 56 categories of information needs related to the interpretation of PDDI information including drug and interaction information; study design; evidence including clinical details, quality and content of reports, and consequences; and potential recommendations. We also identified strengths/weaknesses of PDDI information systems.

conclusionsWe identified the kinds of information that might be most effective for summarizing PDDIs. The drug information experts we interviewed had differing goals, suggesting a need for detailed information models and flexible presentations. Several information needs not discussed in previous work were identified, including temporal overlaps in drug administration, biological plausibility of interactions, and assessment of the quality and content of reports. Richly structured depictions of PDDI information may help drug information experts more effectively interpret data and develop recommendations. Effective information models and system designs will be needed to maximize the utility of this information.

Indexed as

Drug InteractionsDecision Support Systems, ClinicalDrug Information ServicesHumansPractice Guidelines as TopicClinicalClinical recommendationsDecision support systemsDrug information servicesDrug interactionsInformation needs

Identifiers

PMID28228132
PMCPMC5322613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.