Evidence map›Paper›PMID 28228115›Full record

ArticleBMC musculoskeletal disorders2017

Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial.

Stephen P Messier, Leigh F Callahan, Daniel P Beavers, Kate Queen, Shannon L Mihalko, Gary D Miller, Elena Losina, Jeffrey N Katz, Richard F Loeser, Sara A Quandt and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02577549 (Weight Loss and Exercise for Communities With Arthritis in North Carolina), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02577549 nacompletednot on this map

Weight Loss and Exercise for Communities With Arthritis in North Carolina

TypeinterventionalSponsorWake Forest UniversityRan2016 to 2021Enrolled823ConditionsOsteoarthritisArmsDiet & Exercise, Attention Control
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Exercise for osteoarthritis of the knee.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Adult obesity treatment and prevention: A trans-agency commentary on the research landscape, gaps, and future opportunities.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Raman needle arthroscopy for in vivo molecular assessment of cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Stephen P MessierJ.B. Snow Biomechanics Laboratory, Department of Health & Exercise Science, Wake Forest University, Winston-Salem, NC, 27109, USA. messier@wfu.edu.
Leigh F CallahanThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Daniel P BeaversDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kate QueenHaywood Regional Medical Center, Clyde, NC, USA.
Shannon L MihalkoJ.B. Snow Biomechanics Laboratory, Department of Health & Exercise Science, Wake Forest University, Winston-Salem, NC, 27109, USA.
Gary D MillerJ.B. Snow Biomechanics Laboratory, Department of Health & Exercise Science, Wake Forest University, Winston-Salem, NC, 27109, USA.
Elena LosinaOrthopedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jeffrey N KatzOrthopedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Richard F LoeserThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sara A QuandtDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Paul DeVitaDepartment of Kinesiology, East Carolina University, Greenville, NC, USA.
David J HunterRheumatology Department, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.
Mary F LylesSection on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jovita NewmanJ.B. Snow Biomechanics Laboratory, Department of Health & Exercise Science, Wake Forest University, Winston-Salem, NC, 27109, USA.
Betsy HackneyThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Joanne M JordanThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wake Forest University · USUniversity of North Carolina at Chapel Hill · USBrigham and Women's Hospital · USEast Carolina University · USHarvard University · USRegional Medical Center · USUniversity of Sydney · AU

Funding

Weight Loss and Exercise for Communities with Arthritis in North Carolina (WE-CAN)U01AR068658 · NIAMS · WAKE FOREST UNIVERSITY · PI CALLAHAN, LEIGH FLEMING, MESSIER, STEPHEN P · 2015 to 2017
$3.6M
NIAMS NIH HHS U01 AR068658
6 · The paper itself

Abstract

backgroundRecently, we determined that in a rigorously monitored environment an intensive diet-induced weight loss of 10% combined with exercise was significantly more effective at reducing pain in men and women with symptomatic knee osteoarthritis (OA) than either intervention alone. Compared to previous long-term weight loss and exercise trials of knee OA, our intensive diet-induced weight loss and exercise intervention was twice as effective at reducing pain intensity. Whether these results can be generalized to less intensively monitored cohorts is unknown. Thus, the policy relevant and clinically important question is: Can we adapt this successful solution to a pervasive public health problem in real-world clinical and community settings? This study aims to develop a systematic, practical, cost-effective diet-induced weight loss and exercise intervention implemented in community settings and to determine its effectiveness in reducing pain and improving other clinical outcomes in persons with knee OA. METHODS/

designThis is a Phase III, pragmatic, assessor-blinded, randomized controlled trial. Participants will include 820 ambulatory, community-dwelling, overweight and obese (BMI ≥ 27 kg/m DISCUSSION: Many physicians who treat people with knee OA have no practical means to implement weight loss and exercise treatments as recommended by numerous OA treatment guidelines. This study will establish the effectiveness of a community program that will serve as a blueprint and exemplar for clinicians and public health officials in urban and rural communities to implement a diet-induced weight loss and exercise program designed to reduce knee pain and improve other clinical outcomes in overweight and obese adults with knee OA.

trial registrationclinicaltrials.gov Identifier: NCT02577549 October 12, 2015.

Indexed as

Exercise TherapyWeight LossClinical Trials, Phase III as TopicFemaleHumansLife StyleMaleMiddle AgedNorth CarolinaOsteoarthritis, KneeOverweightPainPain ManagementPain MeasurementPragmatic Clinical Trials as TopicQuality of LifeClinical trialCommunity based researchKnee painOsteoarthritisPragmatic

Identifiers

PMID28228115
PMCPMC5322619
OpenAlexW2591065978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.