ReviewArchives of endocrinology and metabolism
Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review.
Review in Archives of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 80 citations in OpenAlex.
- Efficacy and safety of pharmacological and procedural interventions in the management of hypertriglyceridemia-induced acute pancreatitis: a systematic review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026Review
- Potential influence of gut microbiota on the process of hypertriglyceridemia-aggravated acute pancreatitis.World journal of gastroenterology · 2026Review
- Severe Hypertriglyceridemia in Pregnancy: Clinical Approach and Management Strategies.JCEM case reports · 2025Article
- Triglyceride lowering in patients with different severities of hypertriglyceridaemia-associated acute pancreatitis: secondary analysis of a multicentre, prospective cohort study.BMJ open gastroenterology · 2025Article
- Metabolic disturbances in acute pancreatitis: mechanisms and therapeutic implications.Frontiers in endocrinology · 2025Review
- Bioactive Nanomaterials: Comprehensive Monitoring and Regulation of Acute Pancreatitis Induced Acute Lung Injury.International journal of nanomedicine · 2025Review
- Case Report: Severe hypertriglyceridaemia and multivessel coronary artery disease - management and plaque characteristics.Frontiers in cardiovascular medicine · 2025Article
- An unusual case of type I hyperlipidemia - infant with acute encephalopathy, bulging fontanel, vomiting and pink blood: a case report.BMC pediatrics · 2024Article
- Dyslipidemia in Pregnancy: A Systematic Review of Molecular Alterations and Clinical Implications.Biomedicines · 2024Review
- [Management of acute pancreatitis in the emergency department and the intensive care unit].Die Anaesthesiologie · 2024Review
- Diagnosis and stabilisation of familial chylomicronemia syndrome in two infants presenting with hypertriglyceridemia-induced acute pancreatitis.JIMD reports · 2024Article
- [Management of acute pancreatitis in the emergency department and the intensive care unit].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Cornelian Cherry (International journal of molecular sciences · 2024Article
- Retrospective Study of the Use of Heparins in Pregnant Women andJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- A Case of Acute Hypertriglyceridemia-Induced Pancreatitis in Pregnancy and Its Clinical Implications.Case reports in endocrinology · 2024Article
- Treatment and diagnosis of hyperlipidemia acute pancreatitis in pregnancy associated with pre‑pregnancy obesity and diabetes: A case report.Experimental and therapeutic medicine · 2023Article
- Evaluating the efficacy and timing of blood purification modalities in early-stage hyperlipidemic acute pancreatitis treatment.Lipids in health and disease · 2023Review
- Hypertriglyceridemic pancreatitis managed with heparin and insulin: a case report.Journal of medical case reports · 2023Article
- Effectiveness of an Intravenous Insulin-Based Treatment Protocol for the Management of Hypertriglyceridemia-Associated Acute Pancreatitis.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2023Article
- The role of high serum triglyceride levels on pancreatic necrosis development and related complications.BMC gastroenterology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. We successfully used heparin and insulin as first-line therapy in four consecutive patients with acute pancreatitis secondary to hypertriglyceridemia. In a literature search, we revised almost all reports published to date of patients managed successfully with this combination. Heparin and insulin appear to be a safe, effective, and inexpensive first-line therapy for hypertriglyceridemia-associated acute pancreatitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.