Evidence map›Paper›PMID 28225809›Full record

ArticlePloS one2017

The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet.

Sarah J Glastras, Hui Chen, Michael Tsang, Rachel Teh, Rachel T McGrath, Amgad Zaky, Jason Chen, Muh Geot Wong, Carol A Pollock, Sonia Saad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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  18. Impact of early-life diet on long-term renal health.Molecular and cellular pediatrics · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sarah J GlastrasDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Hui ChenSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.
Michael TsangSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.
Rachel TehDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Rachel T McGrathDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Amgad ZakyDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Jason ChenDepartment of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia.
Muh Geot WongDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Carol A PollockDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Sonia SaadDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
University of Sydney · AURoyal North Shore Hospital · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisDevelopmental programming induced by maternal obesity influences the development of chronic disease in offspring. In the present study, we aimed to determine whether maternal obesity exaggerates obesity-related kidney disease.

methodsFemale C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow or HFD. At postnatal Week 8, HFD-fed offspring were administered one dose streptozotocin (STZ, 100 mg/kg i.p.) or vehicle control. Metabolic parameters and renal functional and structural changes were observed at postnatal Week 32.

resultsHFD-fed offspring had increased adiposity, glucose intolerance and hyperlipidaemia, associated with increased albuminuria and serum creatinine levels. Their kidneys displayed structural changes with increased levels of fibrotic, inflammatory and oxidative stress markers. STZ administration did not potentiate the renal effects of HFD. Though maternal obesity had a sustained effect on serum creatinine and oxidative stress markers in lean offspring, the renal consequences of maternal obesity were overwhelmed by the powerful effect of diet-induced obesity.

conclusionMaternal obesity portends significant risks for metabolic and renal health in adult offspring. However, diet-induced obesity is an overwhelming and potent stimulus for the development of CKD that is not potentiated by maternal obesity.

Indexed as

AdiposityAnimalsBiomarkersCreatinineDiet, High-FatFemaleFibrosisGlucose IntoleranceKidneyMaleMaternal Nutritional Physiological PhenomenaMiceMice, Inbred C57BLObesityOxidative StressPregnancyBiomarkersCreatinine

Identifiers

PMID28225809
PMCPMC5321436
OpenAlexW2589139275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.