ArticlePloS one2017
An outbreak of acute respiratory disease caused by a virus associated RNA II gene mutation strain of human adenovirus 7 in China, 2015.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- First detection of human adenovirus type 7 deletion mutant associated with an outbreak of acute respiratory infection.Virology journal · 2026Article
- A theoretical epidemiological investigation into the transmission of respiratory infectious diseases during group meals among military personnel based on an individual-based model.Frontiers in public health · 2025Article
- A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa.Frontiers in public health · 2023Article
- Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults.Viruses · 2021Review
- Review
- Immune Response against Adenovirus in Acute Upper Respiratory Tract Infections in Immunocompetent Children.Vaccines · 2020Article
- An artificially simulated outbreak of a respiratory infectious disease.BMC public health · 2020Article
- Epidemiological analysis of an outbreak of an adenovirus type 7 infection in a boot camp in China.PloS one · 2020Article
- Characterization and genome analysis of novel phage vB_EfaP_IME195 infecting Enterococcus faecalis.Virus genes · 2018Article
- Human adenovirus infections: update and consideration of mechanisms of viral persistence.Current opinion in infectious diseases · 2018Review
- Seroprevalence of Neutralizing Antibodies to Human Adenovirus Type 4 and 7 in Healthy Populations From Southern China.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human adenovirus 7 (HAdV-7) strains are a major cause of acute respiratory disease (ARD) among adults and children, associated with fatal pneumonia. An ARD outbreak caused by HAdV-7 that involved 739 college students was reported in this article. To better understand the underlying cause of this large-scale epidemic, virus strains were isolated from infected patients and sequence variations of the whole genome sequence were detected. Evolutionary trees and alignment results indicated that the major capsid protein genes hexon and fibre were strongly conserved among serotype 7 strains in China at that time. Instead, the HAdV-7 strains presented three thymine deletions in the virus associated RNA (VA RNA) II terminal region. We also found that the mutation might lead to increased mRNA expression of an adjacent gene, L1 52/55K, and thus promoted faster growth. These findings suggest that sequence variation of VA RNA II gene was a potential cause of such a severe HAdV-7 infection and this gene should be a new-emerging factor to be monitored for better understanding of HAdV-7 infection.
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