Evidence map›Paper›PMID 28225568›Full record

ArticleJournal of magnetic resonance imaging : JMRI2017

Liver histology and diffusion-weighted MRI in children with nonalcoholic fatty liver disease: A MAGNET study.

Paul Manning, Paul Murphy, Kang Wang, Jonathan Hooker, Tanya Wolfson, Michael S Middleton, Kimberly P Newton, Cynthia Behling, Hannah I Awai, Janis Durelle and 6 more

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Gender-specific liver aging and magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2021
    Article
  10. Accelerated Acquisition of High-resolution Diffusion-weighted Imaging of the Brain with a Multi-shot Echo-planar Sequence: Deep-learning-based Denoising.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2021
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Paul ManningLiver Imaging Group, Department of Radiology, University of California, San Diego, School of Medicine, San Diego, California, USA.ORCID 0000-0002-2947-3894
Paul MurphyLiver Imaging Group, Department of Radiology, University of California, San Diego, School of Medicine, San Diego, California, USA.
Kang WangLiver Imaging Group, Department of Radiology, University of California, San Diego, School of Medicine, San Diego, California, USA.
Jonathan HookerLiver Imaging Group, Department of Radiology, University of California, San Diego, School of Medicine, San Diego, California, USA.
Tanya WolfsonComputational and Applied Statistics Laboratory (CASL), SDSC, University of California, San Diego, La Jolla, California, USA.
Michael S MiddletonLiver Imaging Group, Department of Radiology, University of California, San Diego, School of Medicine, San Diego, California, USA.
Kimberly P NewtonDepartment of Pediatrics, UCSD and Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA.
Cynthia BehlingDepartment of Pediatrics, UCSD and Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA.
Hannah I AwaiDepartment of Pediatrics, UCSD and Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA.
Janis DurelleDepartment of Pediatrics, UCSD and Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA.
Melissa N PaizDepartment of Pediatrics, UCSD and Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA.
Jorge E AngelesDepartment of Pediatrics, UCSD and Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA.
Diana De La PenaDepartment of Pediatrics, UCSD and Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA.
J Allen McCutchanDepartment of Medicine, UCSD, San Diego, California, USA.
Jeffrey B SchwimmerDepartment of Pediatrics, UCSD and Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA.
Claude B SirlinLiver Imaging Group, Department of Radiology, University of California, San Diego, School of Medicine, San Diego, California, USA.
Rady Children's Hospital-San Diego · USUniversity of California System · USCalifornia College San Diego · USUniversity of California San Diego · US

Funding

Pediatric Trials in Non-Alcoholic Steatohepatitis (NASH)U01DK061734 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2002 to 2026
$24.4M
Continuation of the Non-Alcoholic Steatohepatitis Clinical Research Network (NASHU01DK061730 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2002 to 2018
$23.2M
Non Alcoholic Steatohepatitis Clinical Research NetworkU01DK061732 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2002 to 2026
$12.2M
Pathogenesis, prognosis, and treatment of NAFLD patientsU01DK061713 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ANNA MAE ELIZABETH DIEHL · 2002 to 2026
$10.3M
Collaborative Clinical Research on Non Alcoholic StratohepatitisU01DK061737 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NAGA P CHALASANI · 2002 to 2026
$10.2M
Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)U01DK061738 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Norah A. Terrault · 2002 to 2026
$8.9M
Traning Clinical Scientists in Radiological ImagingT32EB005970 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric Y Chang, Rebecca Ann Rakow-Penner · 2007 to 2026
$3.2M
MR Imaging of Non-Alcoholic Fatty Liver DiseaseR01DK075128 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIRLIN, CLAUDE B · 2006 to 2010
$2.4M
Development of MR Based Biomarker Panels for NAFLD _ A NASH CRN Ancillary StudyR56DK090350 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHWIMMER, JEFFREY BARNETT, SIRLIN, CLAUDE B · 2010 to 2012
$2.2M
San Diego Clinical and Translational Research InstituteTL1TR000098 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2014
$860k
NCATS NIH HHS TL1 TR000098NIBIB NIH HHS T32 EB005970NIDDK NIH HHS R01 DK075128NIDDK NIH HHS R56 DK090350NIDDK NIH HHS U01 DK061713NIDDK NIH HHS U01 DK061730NIDDK NIH HHS U01 DK061732NIDDK NIH HHS U01 DK061734NIDDK NIH HHS U01 DK061737NIDDK NIH HHS U01 DK061738
6 · The paper itself

Abstract

purposeTo determine potential associations between histologic features of pediatric nonalcoholic fatty liver disease (NAFLD) and estimated quantitative magnetic resonance diffusion-weighted imaging (DWI) parameters. MATERIALS AND

methodsThis prospective, cross-sectional study was performed as part of the Magnetic Resonance Assessment Guiding NAFLD Evaluation and Treatment (MAGNET) ancillary study to the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Sixty-four children underwent a 3T DWI scan (b-values: 0, 100, and 500 s/mm

resultsEstimated means ± standard deviations were: ADC: 1.3 (0.94-1.8) × 10

conclusionIn children with NAFLD, steatosis and fibrosis have independent effects on DWI-estimated parameters ADC, D, and F. Further research is needed to determine the underlying mechanisms and clinical implications of these effects. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1149-1158.

Indexed as

AdolescentChildCross-Sectional StudiesDiffusion Magnetic Resonance ImagingFemaleHistological TechniquesHumansLiverMaleNon-alcoholic Fatty Liver DiseaseProspective StudiesADCchildrenDWIintravoxel incoherent motionNAFLDnonalcoholic fatty liver diseasepediatricQIBsquantitative imaging biomarkers

Identifiers

PMID28225568
PMCPMC5568908
OpenAlexW2590383164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.