Evidence map›Paper›PMID 28225438›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2017

Levels of Intracellular Phosphorylated Tenofovir and Emtricitabine Correlate With Natural Substrate Concentrations in Peripheral Blood Mononuclear Cells of Persons Prescribed Daily Oral Truvada for HIV Pre-exposure Prophylaxis.

Richard E Haaland, Angela Holder, Chou-Pong Pau, Alison Swaims-Kohlmeier, Carolyn Dawson, Dawn K Smith, Tebogo M Segolodi, Michael C Thigpen, Lynn A Paxton, Teresa L Parsons and 2 more

Open access · hybridAbstract readClinical TrialLetter
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Richard E Haaland*Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA †Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD.
Angela Holder
Chou-Pong Pau
Alison Swaims-Kohlmeier
Carolyn Dawson
Dawn K Smith
Tebogo M Segolodi
Michael C Thigpen
Lynn A Paxton
Teresa L Parsons
Craig W Hendrix
Clyde E Hart
Centers for Disease Control and Prevention · USNational Center for HIV/AIDS Viral Hepatitis STD and TB Prevention · USJohns Hopkins Medicine · USJohns Hopkins University · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Pre-Exposure ProphylaxisAdultCD4-Positive T-LymphocytesEmtricitabine, Tenofovir Disoproxil Fumarate Drug CombinationFemaleHIV InfectionsHIV Reverse TranscriptaseHumansLymphocyte ActivationMalePhosphorylationReverse Transcriptase InhibitorsSubstrate SpecificityViral LoadEmtricitabine, Tenofovir Disoproxil Fumarate Drug CombinationHIV Reverse TranscriptaseReverse Transcriptase Inhibitors

Identifiers

PMID28225438
PMCPMC5472483
OpenAlexW2589328181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.