ArticleEpilepsia2017
Presurgical language localization with visual naming associated ECoG high- gamma modulation in pediatric drug-resistant epilepsy.
Article in Epilepsia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ECoG high-gamma modulation versus electrical stimulation for presurgical language mapping.Epilepsy & behavior : E&B · 2018Pooled it
- Article
- Perspectives in conducting task-based research in pediatric surgical epilepsy patients.bioRxiv : the preprint server for biology · 2026Article
- Review
- Electrical Cortical Stimulation for Language Mapping in Epilepsy Surgery-A Systematic Review.Brain sciences · 2025Review
- Bipolar and Laplacian montages are suitable for high-gamma modulation language mapping with stereoelectroencephalography.Frontiers in neurology · 2024Article
- Stability of TiACS nano · 2023Article
- Characterization of High-Gamma Activity in Electrocorticographic Signals.Frontiers in neuroscience · 2023Article
- Inter-individual variability in dorsal stream dynamics during word production.The European journal of neuroscience · 2022Article
- Neuronal Circuits Supporting Development of Visual Naming Revealed by Intracranial Coherence Modulations.Frontiers in neuroscience · 2022Article
- A distributed network supports spatiotemporal cerebral dynamics of visual naming.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Spatial-Temporal Functional Mapping Combined With Cortico-Cortical Evoked Potentials in Predicting Cortical Stimulation Results.Frontiers in human neuroscience · 2021Article
- Cognitive and Emotional Mapping With SEEG.Frontiers in neurology · 2021Review
- Combining Gamma With Alpha and Beta Power Modulation for Enhanced Cortical Mapping in Patients With Focal Epilepsy.Frontiers in human neuroscience · 2020Article
- Spatiotemporal dynamics of auditory and picture naming-related high-gamma modulations: A study of Japanese-speaking patients.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Article
- Discrimination of Movement-Related Cortical Potentials Exploiting Unsupervised Learned Representations From ECoGs.Frontiers in neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
objectiveThis prospective study compared presurgical language localization with visual naming-associated high-γ modulation (HGM) and conventional electrical cortical stimulation (ECS) in children with intracranial electrodes.
methodsPatients with drug-resistant epilepsy who were undergoing intracranial monitoring were included if able to name pictures. Electrocorticography (ECoG) signals were recorded during picture naming (overt and covert) and quiet baseline. For each electrode the likelihood of high-γ (70-116 Hz) power modulation during naming task relative to the baseline was estimated. Electrodes with significant HGM were plotted on a three-dimensional (3D) cortical surface model. Sensitivity, specificity, and accuracy were calculated compared to clinical ECS.
resultsSeventeen patients with mean age of 11.3 years (range 4-19) were included. In patients with left hemisphere electrodes (n = 10), HGM during overt naming showed high specificity (0.81, 95% confidence interval [CI] 0.78-0.85), and accuracy (0.71, 95% CI 0.66-0.75, p < 0.001), but modest sensitivity (0.47) when ECS interference with naming (aphasia or paraphasic errors) and/or oral motor function was regarded as the gold standard. Similar results were reproduced by comparing covert naming-associated HGM with ECS naming sites. With right hemisphere electrodes (n = 7), no ECS-naming deficits were seen without interference with oral-motor function. HGM mapping showed a high specificity (0.81, 95% CI 0.78-0.84), and accuracy (0.76, 95% CI 0.71-0.81, p = 0.006), but modest sensitivity (0.44) compared to ECS interference with oral-motor function. Naming-associated ECoG HGM was consistently observed over Broca's area (left posterior inferior-frontal gyrus), bilateral oral/facial motor cortex, and sometimes over the temporal pole. SIGNIFICANCE: This study supports the use of ECoG HGM mapping in children in whom adverse events preclude ECS, or as a screening method to prioritize electrodes for ECS testing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.