Evidence map›Paper›PMID 28225155›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2018

Remotely Supervised Transcranial Direct Current Stimulation Increases the Benefit of At-Home Cognitive Training in Multiple Sclerosis.

Leigh Charvet, Michael Shaw, Bryan Dobbs, Ariana Frontario, Kathleen Sherman, Marom Bikson, Abhishek Datta, Lauren Krupp, Esmail Zeinapour, Margaret Kasschau

5 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 56 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 6 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03833583 nacompletednot on this mapstarted 2019, after this paper: background citation

Transcranial Direct Current Stimulation (tDCS) to Reduce Craving in Cocaine Addiction

TypeinterventionalSponsorSoterix MedicalRan2019 to 2019Enrolled25ConditionsCocaine Use Disorder, Cocaine DependenceArmsSoterix Medical mini-CT tDCS stimulator
NCT04883229 nawithdrawnnot on this mapstarted 2022, after this paper: background citation

tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study

TypeinterventionalSponsorUniversity of California, San FranciscoRan2022 to 2023Enrolled0ConditionsNonfluent Aphasia, Progressive, Primary Progressive Nonfluent Aphasia, Primary Progressive Non Fluent Aphasia, Progressive Supranuclear PalsyArmsHalo Neuroscience Neurostimulator
NCT04994821 phase2completednot on this mapstarted 2020, after this paper: background citation

A Phase 2 Study to Investigate Use of Transcranial Direct Current Stimulation (tDCS) to Reduce Craving in Cocaine Addiction

TypeinterventionalSponsorSoterix MedicalRan2020 to 2022Enrolled60ConditionsCocaine Use Disorder, Cocaine DependenceArmstranscranial direct current stimulator (tDCS), Cognitive Reappraisal
NCT05389592 nacompletednot on this mapstarted 2022, after this paper: background citation

Treatment of COVID-19 Post-acute Cognitive Impairment Sequelae (PASC) With Portable Brain Stimulation: a Double-blind, Randomized-controlled Trial

TypeinterventionalSponsorUniversity of Sao PauloRan2022 to 2023Enrolled60ConditionsCognitive Impairment, Post-Acute Sequelae of SARS-CoV-2 Infection, COVID-19ArmsActive tDCS and cognitive training, Sham tDCS and cognitive training
NCT07114809 narecruitingnot on this mapstarted 2024, after this paper: background citation

Impact of Anodal tDCS and Virtual Reality on Cognitive Dysfunction in Patients With Multiple Sclerosis: a Protocol of a Double Blind, Randomized, Prospective, Controlled Study.

TypeinterventionalSponsorOspedale Policlinico San MartinoRan2024 to 2026Enrolled80ConditionsCognitive Impairment, Multiple SclerosisArmsExperimental group (EG) performing Anodal-tDCS (A-tDCS) and VR, Sham Comparator: Control group (CG) performing sham-tDCS (S-tCDS) and VR
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 6 syntheses or guidelines pooled it, 104 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Leigh CharvetDepartment of Neurology, New York University Langone Medical Center, New York, NY, USA.
Michael ShawDepartment of Neurology, New York University Langone Medical Center, New York, NY, USA.
Bryan DobbsDepartment of Neurology, New York University Langone Medical Center, New York, NY, USA.
Ariana FrontarioLake Erie College of Osteopathic Medicine, Erie, PA, USA.
Kathleen ShermanDepartment of Neurology, New York University Langone Medical Center, New York, NY, USA.
Marom BiksonEngineering Department, City College of New York, New York, NY, USA.
Abhishek DattaSoterix Medical, New York, NY, USA.
Lauren KruppDepartment of Neurology, New York University Langone Medical Center, New York, NY, USA.
Esmail ZeinapourEngineering Department, City College of New York, New York, NY, USA.
Margaret KasschauSchool of Health Technology and Management, Stony Brook Medicine, Stony Brook, NY, USA.
NYU Langone Health · USCity College of New York · USLake Erie College of Osteopathic Medicine · USSoterix Medical (United States) · USStony Brook Medicine · US

Funding

A tool-box to control and enhance tDCS spatial precisionR01MH111896 · NIMH · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2016 to 2019
$2.2M
NIMH NIH HHS R01 MH111896
6 · The paper itself

Abstract

objectiveTo explore the efficacy of remotely-supervised transcranial direct current stimulation (RS-tDCS) paired with cognitive training (CT) exercise in participants with multiple sclerosis (MS).

methodsIn a feasibility study of RS-tDCS in MS, participants completed ten sessions of tDCS paired with CT (1.5 mA × 20 min, dorsolateral prefrontal cortex montage). RS-tDCS participants were compared to a control group of adults with MS who underwent ten 20-min CT sessions through the same remotely supervised procedures. Cognitive outcomes were tested by composite scores measuring change in performance on standard tests (Brief International Cognitive Assessment in MS or BICAMS), basic attention (ANT-I Orienting and Attention Networks, Cogstate Detection), complex attention (ANT-I Executive Network, Cogstate Identification and One-Back), and intra-individual response variability (ANT-I and Cogstate identification; sensitive markers of disease status).

resultsAfter ten sessions, the tDCS group (n = 25) compared to the CT only group (n = 20) had significantly greater improvement in complex attention (p = 0.01) and response variability (p = 0.01) composites. The groups did not differ in measures of basic attention (p = 0.95) or standard cognitive measures (p = 0.99).

conclusionsThese initial findings indicate benefit for RS-tDCS paired with CT in MS. Exploratory analyses indicate that the earliest tDCS cognitive benefit is seen in complex attention and response variability. Telerehabilitation using RS-tDCS combined with CT may lead to improved outcomes in MS.

Indexed as

AdultAgedAttentionCognition DisordersFemaleHumansMaleMemory, Short-TermMiddle AgedMultiple SclerosisNeuropsychological TestsRetrospective StudiesTomography Scanners, X-Ray ComputedTranscranial Direct Current StimulationCognitivemultiple sclerosisremotely supervisedtDCStelerehabilitation

Identifiers

PMID28225155
PMCPMC5975186
OpenAlexW2591224748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.