Evidence map›Paper›PMID 28225079›Full record

ArticleScientific reports2017

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

Marco C Inserra, Mathilde R Israel, Ashlee Caldwell, Joel Castro, Jennifer R Deuis, Andrea M Harrington, Angelo Keramidas, Sonia Garcia-Caraballo, Jessica Maddern, Andelain Erickson and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 73 citations in OpenAlex.

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  16. Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases:International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Marco C InserraCentre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Rd, St Lucia, Queensland 4072, Australia.
Mathilde R IsraelCentre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Rd, St Lucia, Queensland 4072, Australia.
Ashlee CaldwellVisceral Pain Group, South Australian Health and Medical Research Institute (SAHMRI), School of Medicine, Flinders University, Adelaide, South Australia 5000, Australia.
Joel CastroVisceral Pain Group, South Australian Health and Medical Research Institute (SAHMRI), School of Medicine, Flinders University, Adelaide, South Australia 5000, Australia.
Jennifer R DeuisCentre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Rd, St Lucia, Queensland 4072, Australia.
Andrea M HarringtonVisceral Pain Group, South Australian Health and Medical Research Institute (SAHMRI), School of Medicine, Flinders University, Adelaide, South Australia 5000, Australia.
Angelo KeramidasQueensland Brain Institute, The University of Queensland, St Lucia, Queensland 4072, Australia.
Sonia Garcia-CaraballoVisceral Pain Group, South Australian Health and Medical Research Institute (SAHMRI), School of Medicine, Flinders University, Adelaide, South Australia 5000, Australia.
Jessica MaddernVisceral Pain Group, South Australian Health and Medical Research Institute (SAHMRI), School of Medicine, Flinders University, Adelaide, South Australia 5000, Australia.
Andelain EricksonVisceral Pain Group, South Australian Health and Medical Research Institute (SAHMRI), School of Medicine, Flinders University, Adelaide, South Australia 5000, Australia.
Luke GrundyVisceral Pain Group, South Australian Health and Medical Research Institute (SAHMRI), School of Medicine, Flinders University, Adelaide, South Australia 5000, Australia.
Grigori Y RychkovCentre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia.
Katharina ZimmermannKlinik für Anästhesiologie am Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Richard J LewisCentre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Rd, St Lucia, Queensland 4072, Australia.
Stuart M BrierleyVisceral Pain Group, South Australian Health and Medical Research Institute (SAHMRI), School of Medicine, Flinders University, Adelaide, South Australia 5000, Australia.
Irina VetterCentre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Rd, St Lucia, Queensland 4072, Australia.
University of Queensland · AUUniversity of Adelaide · AUSouth Australian Health and Medical Research Institute · AUFlinders University · AUFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human intoxication with the seafood poison ciguatoxin, a dinoflagellate polyether that activates voltage-gated sodium channels (Na

Indexed as

Action PotentialsAnimalsCells, CulturedCiguatoxinsGanglia, SpinalGene Expression RegulationHEK293 CellsHumansMiceProtein IsoformsVoltage-Gated Sodium ChannelsCiguatoxinsProtein IsoformsVoltage-Gated Sodium Channels

Identifiers

PMID28225079
PMCPMC5320492
OpenAlexW2589845804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.