Evidence map›Paper›PMID 28224759›Full record

SynthesisObesity (Silver Spring, Md.)2017

Genomic variants at 20p11 associated with body fat mass in the European population.

Yu-Fang Pei, Hai-Gang Ren, Lu Liu, Xiao Li, Chen Fang, Yun Huang, Wen-Zhu Hu, Wei-Wen Kong, An-Ping Feng, Xin-Yi You and 6 more

Open access · bronzeAbstract readMeta-Analysis
In one paragraph

Synthesis in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Four pleiotropic loci associated with fat mass and lean mass.International journal of obesity (2005) · 2020
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Yu-Fang Pei *Department of Epidemiology and Health Statistics, School of Public Health, Medical College, Soochow University, Suzhou, PR China.
Hai-Gang Ren *Laboratory of Molecular Neuropathology, Department of Pharmacology, School of Pharmaceutical Sciences, Medical College, Soochow University, Suzhou, PR China.
Lu LiuJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, PR China.
Xiao LiJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, PR China.
Chen FangDepartment of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, PR China.
Yun HuangDepartment of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, PR China.
Wen-Zhu HuJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, PR China.
Wei-Wen KongJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, PR China.
An-Ping FengJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, PR China.
Xin-Yi YouJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, PR China.
Wen ZhaoJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, PR China.
Hui ShenDepartment of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Qing TianDepartment of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Yong-Hong ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Medical College, Soochow University, Suzhou, PR China.
Hong-Wen DengDepartment of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Lei ZhangJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, PR China.
Soochow University · CNTulane University · USSecond Affiliated Hospital of Soochow University · CN

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Tony Y. Hu · 2016 to 2026
$25.3M
RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1M
Proteome-wide Expression Study of Osteogenic CellsP50AR055081 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2007 to 2012
$5.0M
ROBUST AND POWERFUL TEST OF CANDIDATE GENES TO BONE MASSR01AR050496 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2004 to 2013
$3.8M
Epigenomewide DNA Methylation Study for Osteoporosis RiskR01AR059781 · NIAMS · TULANE UNIVERSITY OF LOUISIANA · PI DENG, HONG-WEN · 2012 to 2016
$3.1M
Identification of Proteins Important for Male OsteoporosisR01AR057049 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2009 to 2013
$2.4M
Genomic search for bone mass QTLsR01AG026564 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2007 to 2010
$2.3M
SLEEP AND ENTRAINMENT OF SCN FUNCTIONR01HL064278 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STROHL, KINGMAN PERKINS · 1999 to 2002
$871k
Genome-wide association study of periodontitisRC2DE020756 · NIDCR · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN, GENCO, ROBERT J · 2009 to 2009
$173k
Genetics of Osteoporotic Fractures in ChineseR03TW008221 · FIC · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2009 to 2011
$171k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
FIC NIH HHS R03 TW008221NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N02 HL064278NIAMS NIH HHS P50 AR055081NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R01 AR050496NIAMS NIH HHS R01 AR057049NIAMS NIH HHS R01 AR059781NIA NIH HHS R01 AG026564NIDCR NIH HHS RC2 DE020756NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

objectiveBody fat mass (BFM) is more homogeneous and accurate than body total mass in measuring obesity but has rarely been studied. Aiming to uncover the genetic basis of fat-induced obesity, a genome-wide association meta-analysis of BFM, after adjustment by body lean mass, was performed in the European population.

methodsThree samples of European ancestry were included in the meta-analysis: the Framingham Heart Study (N = 6,004), the Kansas City osteoporosis study (N = 2,207), and the Omaha osteoporosis study (N = 968).

resultsAt the genome-wide significance level (α = 5.0×10

conclusionsThese results may provide new insights into the biological mechanism that underlies fat-induced obesity pathology.

Indexed as

Adipose TissueChromosomes, Human, Pair 20Polymorphism, Single NucleotideAdultAgedBody Mass IndexFemaleGenome-Wide Association StudyGenomicsHumansMaleMiddle AgedObesityWhite People

Identifiers

PMID28224759
PMCPMC5373963
OpenAlexW2590299458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.