SynthesisAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2017
Genetic risk variants for social anxiety.
Synthesis in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03170362 (PRIME Care), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PRIME Care (PRecision Medicine In MEntal Health Care)
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- A systematic review of methylome-wide associations with anxiety disorders.Translational psychiatry · 2026Pooled it
- Investigation of polygenic risk scores and subphenotypes in social anxiety disorder.Translational psychiatry · 2026Article
- Parallel Single-Tissue Summary-Data Mendelian Randomization and Functional Validation Identify the ARRDC1 Promoter SNP rs4494021 as a Genetic Marker Associated with Anxiety Disorders.Neuropsychiatric disease and treatment · 2026Article
- The general and specific in anxiety: an ERP study of social and spatial anxiety.Frontiers in human neuroscience · 2026Article
- Eye-tracking evidence of an association between social anxiety and avoidance of threatening faces in healthy women.Frontiers in psychiatry · 2026Article
- Psychiatric genetics in the diverse landscape of Latin American populations.Nature genetics · 2025Review
- Mediating effect of social anxiety on the association between self-esteem and internet addiction among Chinese vocational school students.Frontiers in public health · 2025Article
- Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information.Frontiers in genetics · 2023Article
- The role of developmental caregiving programming in modulating our affiliation tendency and the vulnerability to social anxiety and eating disorders.Frontiers in psychology · 2023Article
- The role of personality traits in mediating the relation between fear of negative evaluation and social interaction anxiety.Frontiers in psychology · 2023Article
- Childhood inhibition predicts adolescent social anxiety: Findings from a longitudinal twin study.Development and psychopathology · 2022Article
- Social anxiety disorder in an adolescent with agenesis of the corpus callosum: a case report.BMC psychiatry · 2022Article
- A Standardized Protocol for the Induction of Specific Social Fear in Mice.Neuroscience bulletin · 2021Article
- From genetics to systems biology of stress-related mental disorders.Neurobiology of stress · 2021Article
- The clinical characterization of the adult patient with an anxiety or related disorder aimed at personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes.Scientific reports · 2021Article
- Heritability of quantitative autism spectrum traits in adults: A family-based study.Autism research : official journal of the International Society for Autism Research · 2021Article
- Transcription Factor Motifs Associated with Anterior Insula Gene Expression Underlying Mood Disorder Phenotypes.Molecular neurobiology · 2021Article
- Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety.Frontiers in genetics · 2021Article
- Genetic and epigenetic analyses of panic disorder in the post-GWAS era.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
Corrections and comments
- Erratum issued
- Republished as
Authors and funding
16 authors at 9 institutions in 1 country.
Funding
Abstract
Social anxiety is a neurobehavioral trait characterized by fear and reticence in social situations. Twin studies have shown that social anxiety has a heritable basis, shared with neuroticism and extraversion, but genetic studies have yet to demonstrate robust risk variants. We conducted genomewide association analysis (GWAS) of subjects within the Army Study To Assess Risk and Resilience in Servicemembers (Army STARRS) to (i) determine SNP-based heritability of social anxiety; (ii) discern genetic risk loci for social anxiety; and (iii) determine shared genetic risk with neuroticism and extraversion. GWAS were conducted within ancestral groups (EUR, AFR, LAT) using linear regression models for each of the three component studies in Army STARRS, and then meta-analyzed across studies. SNP-based heritability for social anxiety was significant (h
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.