ReviewJournal of clinical hypertension (Greenwich, Conn.)2017
The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Renal artery intervention utilizing carbon dioxide angiography.Clinical kidney journal · 2017Article
- Renal denervation using carbon dioxide renal angiography in patients with uncontrolled hypertension and moderate to severe chronic kidney disease.Clinical kidney journal · 2017Article
- Should we take renal denervation with a grain of salt?Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Revisiting angioplasty for renovascular hypertension.Clinical kidney journal · 2017Article
- The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures.Journal of clinical hypertension (Greenwich, Conn.) · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion.
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Registered trials
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