Evidence map›Paper›PMID 28224647›Full record

ArticleMuscle & nerve2018

Electrical impedance myography in individuals with collagen 6 and laminin α-2 congenital muscular dystrophy: a cross-sectional and 2-year analysis.

Carmel Nichols, Minal S Jain, Katherine G Meilleur, Tianxia Wu, James Collins, Melissa R Waite, Jahannaz Dastgir, Anam Salman, Sandra Donkervoort, Tina Duong and 9 more

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Muscle & nerve, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01900132 narecruitingnot on this map

Electrical Impedance Myography: Natural History Studies in Neuromuscular Disorders and Healthy Volunteers

TypeinterventionalSponsorNational Institute of Neurological Disorders and Stroke (NINDS)Ran2013 to 2027Enrolled275ConditionsNeuromuscular Disease, Motor Neuron Disease, Inherited Neuromuscular Conditions, Inherited NeuropathiesArmsEIM testing, Nerve &amp, muscle ultrasonography, Nerve conduction studies, Electromyography (EMG)
NCT07502989 recruitingnot on this mapstarted 2025, after this paper: background citation

Convenient Quantification of Myopathic Change in Muscle Via Electrical Impedance Myography

Typeobservational_patient_registrySponsorBeth Israel Deaconess Medical CenterRan2025 to 2027Enrolled150ConditionsMyopathy, Muscular Dystrophies, Myositis, Myofibrillar MyopathyArmsElectrical Impedance Myography
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Electrical impedance myography (EIM) in a natural history study ofAmyotrophic lateral sclerosis & frontotemporal degeneration · 2020
    Article
  8. Review
  9. Fibrogenesis inFrontiers in molecular neuroscience · 2020
    Review
  10. Article
  11. Rare variant inActa myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2019
    Article
  12. Observational
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 2 countries.

Carmel NicholsMark O. Hatfield Clinical Research Center, National Institutes of Health, Bethesda, Maryland, USA.
Minal S JainMark O. Hatfield Clinical Research Center, National Institutes of Health, Bethesda, Maryland, USA.
Katherine G MeilleurTissue Injury Branch, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA.
Tianxia WuClinical Trials Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
James CollinsMercy Clinic Pediatric Neurology, Springfield, Missouri, USA.
Melissa R WaiteMark O. Hatfield Clinical Research Center, National Institutes of Health, Bethesda, Maryland, USA.
Jahannaz DastgirColumbia University, New York, New York, USA.
Anam SalmanEMG Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10/Room 7-5680, Bethesda, Maryland, 20892-1404, USA.
Sandra DonkervoortNeuromuscular and Neurogenetic Disorders of Childhood Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Tina DuongStanford Children's Health, Palo Alto, California, USA.
Katherine KellerRady Children's Hospital, San Diego, California, USA.
Meganne E LeachNeuromuscular and Neurogenetic Disorders of Childhood Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Donovan J LottUniversity of Florida, Gainesville, Florida, USA.
Michelle N McGuireCincinnati Children's Hospital, Cincinnati, Ohio, USA.
Leslie NelsonUniversity of Texas Southwestern Medical Center, Dallas Texas, USA.
Anne RutkowskiKaiser Permanente SCPMG Cure CMD, Los Angeles, California, USA.
Carole VuillerotHospices Civils de Lyon, Hôpital femme Mère enfant, Bron, France.
Carsten G BönnemannNeuromuscular and Neurogenetic Disorders of Childhood Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Tanya J LehkyEMG Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10/Room 7-5680, Bethesda, Maryland, 20892-1404, USA.
National Institutes of Health · USNational Institute of Neurological Disorders and Stroke · USNational Institutes of Health Clinical Center · USCincinnati Children's Hospital Medical Center · USColumbia University · USCure CMD · USHôpital Femme Mère Enfant · FRMercy Clinic Neurology · USMercy Medical Center · USNational Institute of Nursing Research · USRady Children's Hospital-San Diego · USThe University of Texas Southwestern Medical Center · USUniversity of Chicago · USUniversity of Florida · US

Funding

Molecular and Clinical Manifestations of Matrix and Aggregate MyopathiesZIANS003129 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI BÖNNEMANN, CARSTEN · 2011 to 2025
$52.8M
Research in Congenital Muscle DiseaseZIANR000026 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI MEILLEUR, KATHERINE · 2013 to 2019
$4.5M
Intramural NIH HHS Z99 NR999999Intramural NIH HHS ZIA NR000026
6 · The paper itself

Abstract

introductionElectrical impedance myography (EIM) is a noninvasive electrophysiological technique that characterizes muscle properties through bioimpedance. We compared EIM measurements to function, strength, and disease severity in a population with congenital muscular dystrophy (CMD).

methodsForty-one patients with CMD, either collagen 6 related disorders (COL6-RD; n = 21) or laminin α-2-related disorders (LAMA2-RD; n = 20), and 21 healthy pediatric controls underwent 2 yearly EIM exams. In the CMD cohorts, EIM was compared with functional and strength measurements.

resultsBoth CMD cohorts exhibited change over time and had correlation with disease severity. The 50-kHZ phase correlated well with function and strength in the COL6-RD cohort but not in the LAMA2-RD cohort. DISCUSSION: EIM is a potentially useful measure in clinical studies with CMD because of its sensitivity to change over a 1-year period and correlation with disease severity. For COL6-RD, there were also functional and strength correlations. Muscle Nerve 57: 54-60, 2018.

Indexed as

Electric ImpedanceAdolescentChildChild, PreschoolCohort StudiesCollagen Type VICross-Sectional StudiesFemaleHumansLamininMaleMuscle StrengthMuscular DystrophiesMyographyNeurologic ExaminationRunningCollagen Type VILamininlaminin alpha 2COL6 related dystrophiescongenital muscular dystrophyelectrical impedance myographyLAMA2 related dystrophiesneuromuscular disorders

Identifiers

PMID28224647
PMCPMC6383203
OpenAlexW2923575491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.