Evidence map›Paper›PMID 28224376›Full record

ArticleJournal of nephrology2018

A case of atypical hemolytic uremic syndrome in a second renal transplant.

Nicholas A Zwang, Bing Ho, Yashpal S Kanwar, Brad Lewis, Matthew Cusick, John J Friedewald, Lorenzo Gallon

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicholas A ZwangComprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, USA. nzwang1@uic.edu.ORCID http://orcid.org/0000-0003-3675-5264
Bing HoComprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, USA.
Yashpal S KanwarDepartment of Pathology, Northwestern Memorial Hospital, Chicago, USA.
Brad LewisMachaon Diagnostics, Oakland, CA, USA.
Matthew CusickComprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, USA.
John J FriedewaldComprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, USA.
Lorenzo GallonComprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical hemolytic uremic syndrome (aHUS) has gained increased visibility over several years as an important cause of renal failure. Unfortunately, diagnosis is often difficult because individual courses can be highly variable depending the causative genetic mutations. Here we present the case of a patient with a failed renal allograft and acute failure of a second allograft who was ultimately diagnosed with aHUS. Interestingly, he developed early de novo donor specific antibodies (DSA) after the second renal transplant in context of likely recurrent aHUS. Terminal complement inhibition with eculizumab resulted in prompt improvement of renal allograft function.

Indexed as

Complement ActivationAdultAntibodies, Monoclonal, HumanizedAtypical Hemolytic Uremic SyndromeBiopsyComplement Factor IComplement Inactivating AgentsDNA Mutational AnalysisGenetic Predisposition to DiseaseHumansKidneyKidney TransplantationMaleMutationPhenotypeRecurrenceAntibodies, Monoclonal, HumanizedCFI protein, humanComplement Factor IComplement Inactivating AgentseculizumabAtypical hemolytic uremic syndromeComplement biology.Graft failureHistocompatibilityKidney transplantation

Identifiers

PMID28224376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.