ArticleAnnals of surgical oncology2017
The Impact of Smoking on Sentinel Node Metastasis of Primary Cutaneous Melanoma.
Article in Annals of surgical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Melanoma risk, tumour stage, and melanoma-specific mortality in individuals with diabetes: a systematic review and meta-analysis.BMC cancer · 2024Pooled it
- Smoking Status and Survival in Patients With Early-Stage Primary Cutaneous Melanoma.JAMA network open · 2024Trial
- Impact of particulate matter exposure on melanoma risk: A multicentre case-control study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Observational
- Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Vaping and tumor metastasis: current insights and progress.Cancer metastasis reviews · 2024Review
- Outcomes for smokers who develop melanoma: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- α5-nAChR/ADAM10 signaling mediates nicotine-related cutaneous melanoma progression via STAT3 activation.Archives of dermatological research · 2024Article
- MDFNet: application of multimodal fusion method based on skin image and clinical data to skin cancer classification.Journal of cancer research and clinical oncology · 2023Article
- Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma.Acta dermato-venereologica · 2023Article
- Obesity is not associated with disease-free interval, melanoma-specific survival, or overall survival in patients with clinical stage IB-II melanoma after SLNB.Journal of surgical oncology · 2021Article
- Daily Lifestyle and Cutaneous Malignancies.International journal of molecular sciences · 2021Review
- α9-Containing Nicotinic Receptors in Cancer.Frontiers in cellular neuroscience · 2021Review
- Fine Particulate Matter Air Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- The association of smoking and socioeconomic status on cutaneous melanoma: a population-based, data-linkage, case-control study.The British journal of dermatology · 2020Article
- Association Between Parkinson's Disease and Melanoma: Putting the Pieces Together.Frontiers in aging neuroscience · 2020Article
- Cigarette Smoking and the Risk of Cutaneous Melanoma: A Case-Control Study.Dermatology (Basel, Switzerland) · 2020Article
- Article
- Melanoma & nuclear medicine: new insights & advances.Melanoma management · 2018Review
Corrections and comments
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Authors and funding
26 authors at 19 institutions in 6 countries.
Funding
Abstract
backgroundAlthough a well-established causative relationship exists between smoking and several epithelial cancers, the association of smoking with metastatic progression in melanoma is not well studied. We hypothesized that smokers would be at increased risk for melanoma metastasis as assessed by sentinel lymph node (SLN) biopsy.
methodsData from the first international Multicenter Selective Lymphadenectomy Trial (MSLT-I) and the screening-phase of the second trial (MSLT-II) were analyzed to determine the association of smoking with clinicopathologic variables and SLN metastasis.
resultsCurrent smoking was strongly associated with SLN metastasis (p = 0.004), even after adjusting for other predictors of metastasis. Among 4231 patients (1025 in MSLT-I and 3206 in MSLT-II), current or former smoking was also independently associated with ulceration (p < 0.001 and p < 0.001, respectively). Compared with current smoking, never smoking was independently associated with decreased Breslow thickness in multivariate analysis (p = 0.002) and with a 0.25 mm predicted decrease in thickness.
conclusionThe direct correlation between current smoking and SLN metastasis of primary cutaneous melanoma was independent of its correlation with tumor thickness and ulceration. Smoking cessation should be strongly encouraged among patients with or at risk for melanoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.