Trial reportMolecular and cellular biochemistry2017
Association of single nucleotide polymorphisms of IL23R and IL17 with necrotizing enterocolitis in premature infants.
Trial report in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Candidate gene analysis in pathogenesis of surgically and non-surgically treated necrotizing enterocolitis in preterm infants.Molecular and cellular biochemistry · 2018Trial
- Ontogeny of RORγtCell & bioscience · 2022Article
- Serum HMGB1 level is correlated with serum I-FABP level in neonatal patients with necrotizing enterocolitis.BMC pediatrics · 2021Observational
- IL-17-related signature genes linked to human necrotizing enterocolitis.BMC research notes · 2021Article
- Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis.Clinical epigenetics · 2020Article
- Relationships of interleukin-17 polymorphisms with recurrent aphthous ulcer risk in a Han Chinese population.The Journal of international medical research · 2020Article
- Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.Nature communications · 2020Article
- Association ofPharmacogenomics and personalized medicine · 2020Article
- Correlation between Interleukin-17 gene polymorphism and osteoarthritis susceptibility in Han Chinese population.BMC medical genetics · 2019Article
- Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions.Seminars in fetal & neonatal medicine · 2018Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Necrotizing enterocolitis (NEC) is a severe gastrointestinal inflammatory disease in neonates, particularly in preterm infants. The interleukin (IL) 23/IL17 axis has been shown to play an important role in the gastrointestinal inflammation. However, the association of gene polymorphisms in the IL23/IL17 axis and the development of NEC remains unknown. In this study, we aimed to explore a possible genetic role of IL23R and IL17 in the development of NEC. We identified single nucleotide polymorphisms (SNPs) in IL23R (rs10889677), IL17A (rs2275913), and IL17F (rs763780) by polymerase chain reaction and Sanger sequencing. A total of 102 NEC patients (stage II, n = 75; and stage III, n = 27) and 120 control subjects were recruited for the study. All of the participants were premature (gestational age < 37 weeks). Our results revealed that the combination of the IL17F rs763780 (TC + CC) genotype and the C allele both significantly increased the risk of NEC [odds ratio (OR) 1.89, 95% confidence interval (CI) 1.04-3.43, P = 0.035; OR 1.82, 95% CI 1.06-3.13, P = 0.028, respectively]. Furthermore, the rs763780 (TC + CC) genotype was associated with increased severity of NEC and the incidence of NEC-related perforation [OR 2.80, 95% CI 1.10-7.12, P = 0.031; OR 3.86, 95% CI 1.10-13.53, P = 0.035, respectively]. However, IL23R rs10889677 and IL17A rs2275913 were not associated with the susceptibility to NEC. In conclusion, our data suggest that a variant of IL17F (rs763780) may contribute to the development of NEC.
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