ArticleNeuroscience bulletin2017
Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia.
Article in Neuroscience bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuropsychological dimensions related to alterations of verbal self-monitoring neural networks in schizophrenic language: systematic review.Frontiers in psychiatry · 2024Pooled it
- Double-blind, randomized, placebo-controlled pilot clinical trial with gamma-band transcranial alternating current stimulation for the treatment of schizophrenia refractory auditory hallucinations.Translational psychiatry · 2025Trial
- Candidate Multimodal MRI Markers of Persistent Auditory Verbal Hallucinations: A Controlled Pilot Study.Tomography (Ann Arbor, Mich.) · 2026Observational
- The onco-functional reorganization of language network underlying metaplasticity induced by gliomas.Frontiers in oncology · 2026Article
- Machine learning-based morphological brain analysis in schizophrenia and unaffected siblings: a multisite study of potential risk markers.Frontiers in neuroscience · 2026Article
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- Widespread asymmetries of amygdala nuclei predict auditory verbal hallucinations in schizophrenia.BMC psychiatry · 2024Article
- Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.Neuroscience bulletin · 2024Review
- Imaging Transcriptomics of the Brain for Schizophrenia.Alpha psychiatry · 2024Review
- Functional Connectivity Between Auditory and Medial Temporal Lobe Networks in Antipsychotic-Naïve Patients With First-Episode Schizophrenia Predicts the Effects of Dopamine Antagonism on Auditory Verbal Hallucinations.Biological psychiatry global open science · 2024Article
- Editorial: Mapping psychopathology with MRI and connectivity analysis.Frontiers in human neuroscience · 2023Article
- Aberrant Cerebello-Thalamo-Cortical Functional and Effective Connectivity in First-Episode Schizophrenia With Auditory Verbal Hallucinations.Schizophrenia bulletin · 2022Article
- Perceptual pathways to hallucinogenesis.Schizophrenia research · 2022Article
- Distinct Brain Dynamic Functional Connectivity Patterns in Schizophrenia Patients With and Without Auditory Verbal Hallucinations.Frontiers in human neuroscience · 2022Article
- Mimicking effects of auditory verbal hallucinations on language production at the level of words, sentences and stories.Frontiers in psychology · 2022Article
- Effective Connectivity of the Hippocampus Can Differentiate Patients with Schizophrenia from Healthy Controls: A Spectral DCM Approach.Brain topography · 2021Article
- Brain imaging features in schizophrenia with co-occurring auditory verbal hallucinations and depressive symptoms-Implication for novel therapeutic strategies to alleviate the reciprocal deterioration.Brain and behavior · 2021Review
- The Etiology of Auditory Hallucinations in Schizophrenia: From Multidimensional Levels.Frontiers in neuroscience · 2021Review
- TAPAS: An Open-Source Software Package for Translational Neuromodeling and Computational Psychiatry.Frontiers in psychiatry · 2021Review
- Thalamus Radiomics-Based Disease Identification and Prediction of Early Treatment Response for Schizophrenia.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations (AVHs) in schizophrenia (SZ) remains unclear. In this study, we used stochastic dynamic causal modeling (sDCM) to quantify connections among the left dorsolateral prefrontal cortex (inner speech monitoring), auditory cortex (auditory processing), hippocampus (memory retrieval), thalamus (information filtering), and Broca's area (language production) in 17 first-episode drug-naïve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging. Finally, we performed receiver operating characteristic (ROC) analysis and correlation analysis between image measures and symptoms. sDCM revealed an increased sensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca's area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVH-specific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence.
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