ArticleNeuroImage. Clinical2017
Brain activation to task-irrelevant disorder-related threat in social anxiety disorder: The impact of symptom severity.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Neural correlates of implicit emotion regulation in mood and anxiety disorders: an fMRI meta-analytic review.Scientific reports · 2025Pooled it
- Abnormal neural activation during negative emotion processing in anxiety disorders: a coordinate-based meta-analysis.CNS spectrums · 2024Pooled it
- Cognitive Neural Mechanism of Social Anxiety Disorder: A Meta-Analysis Based on fMRI Studies.International journal of environmental research and public health · 2021Pooled it
- Increased default mode network activation in depression and social anxiety during upward social comparison.Social cognitive and affective neuroscience · 2025Article
- Neural circuit basis of pathological anxiety.Nature reviews. Neuroscience · 2025Review
- Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025Review
- The Underlying Mechanisms of Comorbid Anxiety and Depression Among Young Women: Evidence From Brain Structure and Hormone.Depression and anxiety · 2025Article
- Cognitive Avoidance Is Associated with Decreased Brain Responsiveness to Threat Distractors under High Perceptual Load.Brain sciences · 2023Article
- Relationship between Overweight/Obesity and Social Communication in Autism Spectrum Disorder Children: Mediating Effect of Gray Matter Volume.Brain sciences · 2023Article
- Relations between lab indices of emotion dysregulation and negative affect reactivity in daily life in two independent studies.Journal of affective disorders · 2022Article
- The long-term associations between parental behaviors, cognitive function and brain activation in adolescence.Scientific reports · 2021Article
- Neural Correlates of Self-referential Processing and Their Clinical Implications in Social Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Review
- Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls.NeuroImage. Clinical · 2019Article
- Neuroimaging Predictors and Mechanisms of Treatment Response in Social Anxiety Disorder: an Overview of the Amygdala.Current psychiatry reports · 2018Review
- Gray Matter Structural Alterations in Social Anxiety Disorder: A Voxel-Based Meta-Analysis.Frontiers in psychiatry · 2018Review
- Social Feedback Modulates Neural Response Associated With Cognitive Bias in Individuals Expressing Anxious Symptoms.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unintentional and uncontrollable processing of threat has been suggested to contribute to the pathology of social anxiety disorder (SAD). The present study investigated the neural correlates of processing task-irrelevant, highly ecologically valid, disorder-related stimuli as a function of symptom severity in SAD. Twenty-four SAD patients and 24 healthy controls (HC) performed a feature-based comparison task during functional magnetic resonance imaging, while task-irrelevant, disorder-related or neutral scenes were presented simultaneously at a different spatial position. SAD patients showed greater activity than HC in response to disorder-related versus neutral scenes in brain regions associated with self-referential processing (e.g. insula, precuneus, dorsomedial prefrontal cortex) and emotion regulation (e.g. dorsolateral prefrontal cortex (dlPFC), inferior frontal gyrus). Symptom severity was positively associated with amygdala activity, and negatively with activation in dorsal anterior cingulate cortex and dlPFC in SAD patients. Additional correlation analysis revealed that amygdala-prefrontal coupling was positively associated with symptom severity. A network of brain regions is thus involved in SAD patients' processing of task-irrelevant, complex, ecologically valid, disorder-related scenes. Furthermore, increasing symptom severity in SAD patients seems to reflect a growing imbalance between neural mechanisms related to stimulus-driven bottom-up and regulatory top-down processes resulting in dysfunctional regulation strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.