ArticleGastroenterology and hepatology from bed to bench2016
Introduction of inflammatory bowel disease biomarkers panel using protein-protein interaction (PPI) network analysis.
Article in Gastroenterology and hepatology from bed to bench, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development.Frontiers in genetics · 2022Pooled it
- Mitogen-Activated Protein Kinase-3 (MAPK3) Is the Main Target of Microsecond Pulsed Electric Field in Human Medulloblastoma.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Transcriptome profiling by RNA sequencing reveals novel targets of Gemini nano curcumin on p53-mutant HT-29 colorectal cancer cells.Journal, genetic engineering & biotechnology · 2025Article
- Exposure of Toluene Diisocyanate Induces DUSP6 and p53 through Activation of TRPA1 Receptor.International journal of molecular sciences · 2022Article
- A systems biology analysis of protein-protein interaction of digestive disorders and Covid-19 virus based on comprehensive gene information.Gastroenterology and hepatology from bed to bench · 2022Article
- Elucidating potential molecular signatures through host-microbe interactions for reactive arthritis and inflammatory bowel disease using combinatorial approach.Scientific reports · 2020Article
- Peripheral blood miR-372 as a biomarker for ulcerative colitis via direct targeting of NLRP12.Experimental and therapeutic medicine · 2019Article
- Contribution of NOTCH signaling pathway along with TNF-α in the intestinal inflammation of ulcerative colitis.Gastroenterology and hepatology from bed to bench · 2019Article
- Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology.Gastroenterology and hepatology from bed to bench · 2019Article
- Investigation of health benefits of cocoa in human colorectal cancer cell line, HT-29 through interactome analysis.Gastroenterology and hepatology from bed to bench · 2019Article
- Protein Interaction Mapping related to Becker Muscular Dystrophy.Iranian journal of child neurology · 2019Article
- Inducible nitric oxide synthase as a potential blood-based biomarker in inflammatory bowel diseases.Gastroenterology and hepatology from bed to bench · 2018Article
- Dietary Phenethyl Isothiocyanate Protects Mice from Colitis Associated Colon Cancer.International journal of molecular sciences · 2017Article
- A systems biology analysis protein-protein interaction of NASH and IBD based on comprehensive gene information.Gastroenterology and hepatology from bed to bench · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn the present study, a protein-protein interaction network construction is conducted for IBD.
backgroundInflammatory bowel diseases as serious chronic gastrointestinal disorders attracted many molecular investigations. Diverse molecular information is present for IBD. However, these molecular findings are not highlighted based on interactome analysis. On the other hand, PPI network analysis is a powerful method for study of molecular interactions in the protein level that provide useful information for highlighting the desired key proteins.
methodsCytoscape is the used software with its plug-ins for detailed analysis. Two centrality parameters including degree and betweenness are determined and the crucial proteins based on these parameters are introduced.
resultsThe 75 proteins among 100 initial proteins are included in the network of IBD. Seventy-five nodes and 260 edges constructed the network as a scale free network. The findings indicate that there are seven hub-bottleneck proteins in the IBD network.
conclusionMore examination revealed the essential roles of these key proteins in the integrity of the network. Finally, the indicator panel including NFKB1, CD40, TNFA, TYK2, NOD2, IL23R, and STAT3 is presented as a possible molecular index for IBD.
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Identifiers
28224022PMC5310794What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.