Evidence map›Paper›PMID 28223929›Full record

ArticleFrontiers in human neuroscience2017

The Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain.

Andrew C Peterson, Sheng Zhang, Sien Hu, Herta H Chao, Chiang-Shan R Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrew C PetersonFrank H. Netter MD School of Medicine at Quinnipiac University North Haven, CT, USA.
Sheng ZhangDepartment of Psychiatry, Yale University School of Medicine New Haven, CT, USA.
Sien HuDepartment of Psychiatry, Yale University School of Medicine New Haven, CT, USA.
Herta H ChaoDepartment of Internal Medicine, Yale University School of MedicineNew Haven, CT, USA; Veterans Administration Medical CenterWest Haven, CT, USA.
Chiang-Shan R LiDepartment of Psychiatry, Yale University School of MedicineNew Haven, CT, USA; Department of Neuroscience, Yale University School of MedicineNew Haven, CT, USA; Interdepartmental Neuroscience Program, Yale University School of MedicineNew Haven, CT, USA.
Yale University · USQuinnipiac University · US

Funding

Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Cognitive control and cocaine dependence: thalamic noradrenergic processesR01DA023248 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2008 to 2018
$4.0M
Cerebral Correlates of Early Habitual DrinkingR01AA021449 · NIAAA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2013 to 2017
$1.2M
Thalamic cortical dysfunction and predictors of relapse in cocaine dependenceK25DA040032 · NIDA · YALE UNIVERSITY · PI ZHANG, SHENG · 2015 to 2019
$834k
Imaging Cognitive Control in Cocaine DependenceK02DA026990 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2009 to 2013
$639k
NIAAA NIH HHS R01 AA021449NIDA NIH HHS K02 DA026990NIDA NIH HHS K25 DA040032NIDA NIH HHS R01 DA023248
6 · The paper itself

Abstract

Dysfunction of the dopaminergic ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) is implicated in psychiatric disorders including attention-deficit/ hyperactivity disorder (ADHD), addiction, schizophrenia and movement disorders such as Parkinson's disease (PD). Although the prevalence of these disorders varies by age and sex, the underlying neural mechanism is not well understood. The objective of this study was to delineate the distinct resting state functional connectivity (rsFC) of the VTA and SNc and examine the effects of age, from young to middle-adulthood, and sex on the rsFC of these two dopaminergic structures in a data set of 250 healthy adults (18-49 years of age, 104 men). Using blood oxygenation level dependent (BOLD) signals, we correlated the time course of the VTA and SNc to the time courses of all other brain voxels. At a corrected threshold, paired

Indexed as

agingfunctional connectivitysex differencesubstantia nigraventral tegmental area

Identifiers

PMID28223929
PMCPMC5293810
OpenAlexW2586895084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.