ArticleNeuropsychiatric disease and treatment2017
Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia.
Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review.Frontiers in human neuroscience · 2025Pooled it
- Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Narrative identity in the psychosis spectrum: A systematic review and developmental model.Clinical psychology review · 2021Pooled it
- Functional gradient reorganization and transcriptomic signatures underlying 1 Hz rTMS treatment in first-episode schizophrenia following right orbitofrontal cortex stimulation.NeuroImage. Clinical · 2026Trial
- Targeting auditory verbal hallucinations in schizophrenia: effective connectivity changes induced by low-frequency rTMS.Translational psychiatry · 2024Trial
- Neuroradiological features across major psychiatric disorders and behavioral variant of Alzheimer's disease: a concise multimodal synthesis.Psychoradiology · 2026Review
- Altered Functional Connectivity of Amygdala Subregions with Large-Scale Brain Networks in Schizophrenia: A Resting-State fMRI Study.Tomography (Ann Arbor, Mich.) · 2025Article
- Diagnostic value of regional homogeneity and fractional amplitude of low-frequency fluctuations in the classification of schizophrenia and bipolar disorders.European archives of psychiatry and clinical neuroscience · 2025Article
- Multi-feature fusion RFE random forest for schizophrenia classification and treatment response prediction.Scientific reports · 2025Article
- MRI-based insights into brain structural and functional alterations in schizophrenia treated with risperidone.Frontiers in psychiatry · 2025Review
- Exploring global and local processes underlying alterations in resting-state functional connectivity and dynamics in schizophrenia.Frontiers in psychiatry · 2024Article
- Short-term Medication Effects on Brain Functional Activity and Network Architecture in First-Episode psychosis: a longitudinal fMRI study.Brain imaging and behavior · 2023Article
- Normative model detects abnormal functional connectivity in psychiatric disorders.Frontiers in psychiatry · 2023Article
- Deviant spontaneous neural activity as a potential early-response predictor for therapeutic interventions in patients with schizophrenia.Frontiers in neuroscience · 2023Article
- Early-life stress exposure and large-scale covariance brain networks in extremely preterm-born infants.Translational psychiatry · 2022Article
- Abnormal Large-Scale Neuronal Network in High Myopia.Frontiers in human neuroscience · 2022Article
- Aberrant default mode connectivity in adolescents with early-onset psychosis: A resting state fMRI study.NeuroImage. Clinical · 2022Article
- Dissecting autism and schizophrenia through neuroimaging genomics.Brain : a journal of neurology · 2021Review
- Aberrant triple-network connectivity patterns discriminate biotypes of first-episode medication-naive schizophrenia in two large independent cohorts.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Dynamic functional connectivity and its anatomical substrate reveal treatment outcome in first-episode drug-naïve schizophrenia.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAbnormal resting-state functional connectivity (FC), particularly in the default mode network (DMN) and the salience network (SN), has been reported in schizophrenia, but little is known about the effects of antipsychotics on these networks. The purpose of this study was to examine the effects of atypical antipsychotics on DMN and SN and the relationship between these effects and symptom improvement in patients with schizophrenia.
methodsThis was a prospective study of 33 patients diagnosed with schizophrenia and treated with antipsychotics at Shanghai Mental Health Center. Thirty-three healthy controls matched for age and gender were recruited. All subjects underwent functional magnetic resonance imaging (fMRI). Healthy controls were scanned only once; patients were scanned before and after 6-8 weeks of treatment.
resultsIn the DMN, the patients exhibited increased FC after treatment in the right superior temporal gyrus, right medial frontal gyrus, and left superior frontal gyrus and decreased FC in the right posterior cingulate/precuneus (
conclusionThese findings suggest that atypical antipsychotics could regulate the FC of certain key brain regions within the DMN in early-phase schizophrenia, which might be related to symptom improvement. However, the effects of atypical antipsychotics on SN are less clear.
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