ArticleInternational journal of chronic obstructive pulmonary disease2017
Airway gene expression of IL-1 pathway mediators predicts exacerbation risk in obstructive airway disease.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Review
- Neutrophil-related gene expression profile is associated with future paediatric bronchiectasis exacerbations.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Dynamic changes of immune cells and therapeutic responses in experimental models of COPD.Frontiers in immunology · 2026Review
- Integrated miRNA-mRNA network analysis identifies miR-182-5p as a potential regulator in COPD pathogenesis.Frontiers in medicine · 2026Article
- Innate epithelial and functional differences in airway epithelium of children with acute wheeze.Frontiers in cell and developmental biology · 2025Article
- Shared genetic aetiology of respiratory diseases: a genome-wide multitraits association analysis.BMJ open respiratory research · 2024Article
- Different Transcriptome Features of Peripheral Blood Mononuclear Cells in Non-Emphysematous Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2023Article
- Increased expression of miR146a dysregulates TLR2-induced HBD2 in airway epithelial cells from patients with COPD.ERJ open research · 2023Article
- Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection.Frontiers in medicine · 2022Article
- Inflammatory phenotype modulation in the respiratory tract and systemic circulation of e-cigarette users: a pilot study.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Precision cut lung slices: an ex vivo model for assessing the impact of immunomodulatory therapeutics on lung immune responses.Archives of toxicology · 2021Article
- Investigation of a Hypoxia-Immune-Related Microenvironment Gene Signature and Prediction Model for Idiopathic Pulmonary Fibrosis.Frontiers in immunology · 2021Article
- Transforming Growth Factor-β1 Promotes M1 Alveolar Macrophage Polarization in Acute Lung Injury by Up-Regulating DNMT1 to Mediate the microRNA-124/PELI1/IRF5 Axis.Frontiers in cellular and infection microbiology · 2021Article
- Gene-Based Analysis Reveals Sex-Specific Genetic Risk Factors of COPD.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2021Article
- A Sputum 6 Gene Expression Signature Predicts Inflammatory Phenotypes and Future Exacerbations of COPD.International journal of chronic obstructive pulmonary disease · 2020Article
- Molecularly Distinct NLRP3 Inducers Mediate Diverse Ratios of Interleukin-1Mediators of inflammation · 2020Article
- Genetic underpinnings of lung function and COPD.Journal of genetics · 2019Review
- IRAK-M Associates with Susceptibility to Adult-Onset Asthma and Promotes Chronic Airway Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Bioinformatics-based identification of potential microRNA biomarkers in frequent and non-frequent exacerbators of COPD.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExacerbations of asthma and COPD are a major cause of morbidity and mortality and are responsible for significant health care costs. This study further investigates interleukin (IL)-1 pathway activation and its relationship with exacerbations of asthma and COPD.
methodsIn this prospective cohort study, 95 participants with stable asthma (n=35) or COPD (n=60) were recruited and exacerbations recorded over the following 12 months. Gene expressions of IL-1 pathway biomarkers, including the IL-1 receptors (
resultsOf the 95 participants, 89 completed the exacerbation follow-up, where 30 participants (n=22 COPD, n=8 asthma) had two or more exacerbations. At the baseline visit, expressions of IRAK2, IRAK3, PELI1, and IL1R1 were elevated in participants with frequent exacerbations of both asthma and COPD combined and separately. In the combined population, sputum gene expression of IRAK3 (AUC=75.4%;
conclusionThe upregulation of IL-1 pathway mediators is associated with frequent exacerbations of obstructive airway disease. Further studies should investigate these mediators as both potential diagnostic biomarkers predicting at-risk patients and novel treatment targets.
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