ArticleInternational journal of chronic obstructive pulmonary disease2017
Asthma-COPD overlap syndrome in the US: a prospective population-based analysis of patient-reported outcomes and health care utilization.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- A 3-year prospective study to assess clinical characteristics and risk factors for exacerbations in patients with asthma-COPD overlap based on the GINA guideline compared with patients with asthma and COPD.Respiratory research · 2026Article
- Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria.Journal of pharmaceutical policy and practice · 2026Review
- Effectiveness of Benralizumab in Reducing Asthma and COPD Exacerbations in Patients with Severe Asthma and Concomitant COPD: Real-World Evidence from the ZEPHYR-5 Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Disease Burden and Health-Related Quality of Life (HRQoL) of Chronic Obstructive Pulmonary Disease (COPD) in the US - Evidence from the Medical Expenditure Panel Survey (MEPS) from 2016-2019.International journal of chronic obstructive pulmonary disease · 2024Article
- Bronchial Asthma, Airway Remodeling and Lung Fibrosis as Successive Steps of One Process.International journal of molecular sciences · 2023Review
- Asthma-COPD Overlap in Clinical Practice (ACO_CP 2023): Toward Precision Medicine.Journal of personalized medicine · 2023Review
- Alteration of the Respiratory Microbiome in Hospitalized Patients with Asthma-COPD Overlap during and after an Exacerbation.Journal of clinical medicine · 2023Article
- Limitations in Activities of Daily Living among Older Adults with COPD, Asthma, or Asthma-COPD Overlap Residing in Spain.International journal of environmental research and public health · 2023Article
- Phenotype of Asthma-COPD Overlap in COPD and Severe Asthma Cohorts.Journal of Korean medical science · 2022Article
- Comparison of Clinical Characteristics and Short-Term Prognoses Within Hospitalized Chronic Obstructive Pulmonary Disease Patients Comorbid With Asthma, Bronchiectasis, and Their Overlaps: Findings From the ACURE Registry.Frontiers in medicine · 2022Article
- Asthma-COPD overlap in World Trade Center Health Registry enrollees, 2015-2016.The Journal of asthma : official journal of the Association for the Care of Asthma · 2021Article
- Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes.Scientific reports · 2021Article
- Prevalence of COPD among workers with work-related asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020Article
- Asthma-chronic obstructive pulmonary disease overlap syndrome.Current opinion in immunology · 2020Review
- Serum IL-8 and VEGFA are Two Promising Diagnostic Biomarkers of Asthma-COPD Overlap Syndrome.International journal of chronic obstructive pulmonary disease · 2020Article
- Controversies in Allergy: Is Asthma Chronic Obstructive Pulmonary Disease Overlap a Distinct Syndrome That Changes Treatment and Patient Outcomes?The journal of allergy and clinical immunology. In practice · 2019Review
- Asthma-COPD Overlap Syndrome.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Article
- Health-related quality of life predicted subsequent health care resource utilization in patients with active cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Health characteristics of patients with asthma, COPD and asthma-COPD overlap in the NHANES database.International journal of chronic obstructive pulmonary disease · 2018Article
- Contributions of COPD, asthma, and ten comorbid conditions to health care utilization and patient-centered outcomes among US adults with obstructive airway disease.International journal of chronic obstructive pulmonary disease · 2017Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundPrior work suggests that asthma-COPD overlap syndrome (ACOS) has a greater health burden than asthma alone or COPD alone. In the current study, we have further evaluated the health burden of ACOS in a nationally representative sample of the US population, focusing on patient-reported outcomes and health care utilization and on comparisons with asthma alone and COPD alone. Patient-reported outcomes are especially meaningful, as these include functional activities that are highly valued by patients and are the basis for patient-centered care.
methodsUsing data from the Medical Expenditure Panel Survey (MEPS), we evaluated patient-reported outcomes and health care utilization among participants who were aged 40-85 years and had self-reported, physician-diagnosed asthma or COPD. MEPS administered five rounds of interviews, at baseline and approximately every 6 months over 2.5 years. Patient-reported outcomes included activities of daily living (ADLs), mobility, social/recreational activities, disability days in bed, and health status (Short Form 12, Version 2). Health care utilization included outpatient and emergency department (ED) visits, and hospitalization.
resultsOf 3,486 participants with asthma or COPD, 1,585 (45.4%) had asthma alone, 1,294 (37.1%) had COPD alone, and 607 (17.4%) had ACOS. Relative to asthma alone, ACOS was significantly associated with higher odds of prevalent disability in ADLs and limitations in mobility and social/recreational activities (adjusted odds ratios [adjORs]: 1.91-3.98), as well as with higher odds of incident limitations in mobility and social/recreational activities, disability days in bed, and respiratory-based outpatient and ED visits, and hospitalization (adjORs: 1.86-2.35). In addition, ACOS had significantly worse physical and mental health scores than asthma alone (
conclusionIn the US, ACOS is associated with a greater health burden, including patient-reported outcomes and health care utilization, relative to asthma alone and COPD alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.