Evidence map›Paper›PMID 28223710›Full record

ArticleScientific reports2017

High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease.

Sechang Oh, Rina So, Takashi Shida, Tomoaki Matsuo, Bokun Kim, Kentaro Akiyama, Tomonori Isobe, Yoshikazu Okamoto, Kiyoji Tanaka, Junichi Shoda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 9 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 9 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Pooled it
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  9. The egyptian clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Guideline
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  18. Myokines and mitochondrial function in cardiometabolic diseases.Journal of physiology and biochemistry · 2026
    Review
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sechang OhThe Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, Ibaraki, 305-8576, Japan.
Rina SoJapan Society for the Promotion of Science, Tokyo, 102-0083, Japan.
Takashi ShidaGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, 305-8575, Japan.
Tomoaki MatsuoNational Institute of Occupational Safety and Health, Kanagawa, 214-8585, Japan.
Bokun KimFaculty of Sports Health Care, Inje University, Gyeongsangnamdo, 50834, Republic of Korea.
Kentaro AkiyamaJapan Society for the Promotion of Science, Tokyo, 102-0083, Japan.
Tomonori IsobeFaculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Yoshikazu OkamotoFaculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Kiyoji TanakaFaculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, 305-8575, Japan.
Junichi ShodaThe Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, Ibaraki, 305-8576, Japan.
University of Tsukuba · JPNational Institute of Occupational Safety and Health · JPInje University · KRJapan Society for the Promotion of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We compared the effects of 12-week programs of resistance training (RT), high-intensity interval aerobic training (HIAT), and moderate-intensity continuous aerobic training (MICT). The primary goal was to evaluate the therapeutic effects of the exercise modalities for the management of nonalcoholic fatty liver disease (NAFLD). A total of 61 sedentary obese men with NAFLD were randomized into one of the following exercise regimens (RT, HIAT, or MICT). Hepatic fat content was decreased to a similar extent in the RT, HIAT, and MICT groups (-14.3% vs. -13.7% vs. -14.3%) without significant changes in weight and visceral fat. The gene expression levels of fatty acid synthesis were significantly decreased in the subjects' monocytes. Hepatic stiffness was decreased only in the HIAT group (-16.8%). The stiffness change was associated with restored Kupffer cell phagocytic function (+17.8%) and decreased levels of inflammation such as leptin (-13.2%) and ferritin (-14.1%). RT, HIAT, and MICT were equally effective in reducing hepatic fat content, but only HIAT was effective in improving hepatic stiffness and restoring Kupffer cell function. These benefits appeared to be independent of detectable weight and visceral fat reductions; the benefits were acquired through the modulation of in vivo fatty acid metabolism and obesity-related inflammatory conditions.

Indexed as

ExerciseDiffusion Tensor ImagingFatty Acid SynthasesFerritinsHumansIntra-Abdominal FatKupffer CellsLeptinLeukocytes, MononuclearLipid MetabolismLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseObesityResistance TrainingFatty Acid SynthasesFerritinsLeptin

Identifiers

PMID28223710
PMCPMC5320441
OpenAlexW2590963273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.