ArticleOncotarget2017
Skip lateral lymph node metastasis leaping over the central neck compartment in papillary thyroid carcinoma.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review.BMC surgery · 2019Pooled it
- Clinicopathologic Predictors and Nodal Burden Pattern of Skip Metastasis in Papillary Thyroid Carcinoma: A Multicenter Study.Head & neck · 2026Article
- Interpretable machine learning distinguishes skip from continuous metastasis in N1b papillary thyroid carcinoma.Scientific reports · 2026Article
- Skip metastases in papillary thyroid carcinoma: evidence from a multicenter European retrospective study.Frontiers in endocrinology · 2026Observational
- Predicting the Unexpected: Clinicopathological Insights into Skip Metastasis in Papillary Thyroid Carcinoma.Journal of clinical medicine · 2025Article
- The prognostic implication of skip metastasis to lateral neck in patients with papillary thyroid cancer.Quantitative imaging in medicine and surgery · 2024Article
- Risk factors analysis of lateral cervical lymph node metastasis in papillary thyroid carcinoma: a retrospective study of 830 patients.World journal of surgical oncology · 2024Article
- Surgical Complications in Papillary Thyroid Cancer Patients with Cervical Lymph Node Metastases.Clinical Medicine Insights. Oncology · 2024Article
- Single-center external validation and reconstruction of multiple predictive models for skip lateral lymph node metastasis in papillary thyroid carcinoma.Frontiers in endocrinology · 2024Article
- Interpretable machine learning models for predicting skip metastasis in cN0 papillary thyroid cancer based on clinicopathological and elastography radiomics features.Frontiers in oncology · 2024Article
- Risk factors associated with lymph node metastasis in papillary thyroid cancer: a retrospective analysis based on 2,428 cases.Frontiers in oncology · 2024Article
- Investigating the Involvement of Mediastinal Lymph Nodes in Patients with Papillary Thyroid Carcinoma.Advanced biomedical research · 2024Article
- Risk factors associated with preferential lateral lymph node metastasis in papillary thyroid carcinoma.Cancer medicine · 2023Article
- Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma.Oncology letters · 2023Article
- [Contrast-enhanced ultrasonography with intra-glandular contrast injection can improve the diagnostic accuracy of central compartment lymph node metastasis of thyroid cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Combining Clinicopathologic and Ultrasonic Features for Predicting Skip Metastasis of Lateral Lymph Nodes in Papillary Thyroid Carcinoma.Cancer management and research · 2023Article
- Predicting skip metastasis in lateral lymph nodes of papillary thyroid carcinoma based on clinical and ultrasound features.Frontiers in endocrinology · 2023Article
- Effect of skip metastasis to lateral neck lymph nodes on outcome of patients with papillary thyroid carcinoma.Langenbeck's archives of surgery · 2022Article
- Papillary thyroid cancer: the value of bilateral diagnostic lymphadenectomy.Langenbeck's archives of surgery · 2022Article
- The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview.Molecules (Basel, Switzerland) · 2022Review
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6 authors.
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Abstract
objectiveThis study was performed to investigate the frequency and pattern as well as the predictive factors of skip metastasis (lateral cervical lymph node metastasis without central lymph node metastasis) in papillary thyroid carcinoma (PTC).
methods450 PTC patients who received total thyroidectomy with central neck dissection(CND) combined with modified radical lateral neck dissection(LND) were divided into two groups: with or without skip metastases. The clinicopathological characteristics were statistically compared and analyzed, and univariate and multivariate analyses were performed to detect the risk factors of skip metastasis.
resultsThe skip metastasis rate was 8.7% (39/450), and patients with skip metastases had fewer lateral lymph node metastases but were more likely to have single-level lateral metastasis, which are considered Level II(P<0.05). Skip metastasis was significantly associated with the primary tumor location in the upper portion (OR=18.495, 95% CI 6.612-51.731), a primary tumor size ≤10mm (OR=32.492, 95% CI 11.973-88.174) and Capsule invasion (OR=5.822, 95% CI 1.954-17.343) as demonstrated by our prospective study of 10 patients who received an injection of 0.1 ml carbon nanoparticles under ultrasonography in the upper portion of the lobe: 7(70%) had lateral compartment lymph node black staining without ipsilateral center compartment lymph node staining. However, skip metastasis did not affect the PTC patients' long-term tumor-free survival rate (P=0.432).
conclusionSkip metastases can be common, and the primary tumor location in the upper portion, a primary tumor size ≤10 mm, and capsular invasion are closely linked to skip metastasis. The lateral compartment should be carefully evaluated.
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