Evidence map›Paper›PMID 28223523›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons.

Jinsheng Dong, Colin Echeverría Aitken, Anil Thakur, Byung-Sik Shin, Jon R Lorsch, Alan G Hinnebusch

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Review
  3. Interplay of the ribosome A and CAR sites.NAR genomics and bioinformatics · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A dynamic compositional equilibrium governs mRNA recognition by eIF3.bioRxiv : the preprint server for biology · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Article
  16. Ribosomal RNA 2'-Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Article
  18. Article
  19. Arginine Methylation Regulates Ribosome CAR Function.International journal of molecular sciences · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinsheng DongLaboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Colin Echeverría AitkenLaboratory on the Mechanism and Regulation of Protein Synthesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Anil ThakurLaboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Byung-Sik ShinLaboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Jon R LorschLaboratory on the Mechanism and Regulation of Protein Synthesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 ahinnebusch@nih.gov jon.lorsch@nih.gov.
Alan G HinnebuschLaboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892; ahinnebusch@nih.gov jon.lorsch@nih.gov.ORCID 0000-0002-1627-8395

Funding

Translational & Transcriptional Control Of Gene Expression By Nutrients In YeastZIAHD001004 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI HINNEBUSCH, ALAN G · 2009 to 2025
$34.4M
Elucidating the Molecular Mechanics of Eukaryotic Translation Initiation and Its ControlZIAHD008940 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LORSCH, JON · 2014 to 2025
$9.5M
KINETIC DISSECTION OF EUKARYOTIC TRANSLATION INITIATIONR01GM062128 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 2000 to 2013
$4.6M
NIGMS NIH HHS R01 GM062128
6 · The paper itself

Abstract

The eukaryotic 43S preinitiation complex (PIC) bearing Met-tRNA

Indexed as

Codon, InitiatorPeptide Chain Initiation, TranslationalAllelesAmino Acid SubstitutionEukaryotic Initiation Factor-5Models, MolecularMultiprotein ComplexesMutationPhenotypeProtein BindingProtein ConformationProtein StabilityRibosomal ProteinsRibosome Subunits, Small, EukaryoticRNA, MessengerCodon, InitiatorEukaryotic Initiation Factor-5Multiprotein ComplexesRibosomal Proteinsribosomal protein S3RNA, MessengerinitiationribosometranslationuS3yeast

Identifiers

PMID28223523
PMCPMC5358355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.