ArticleProceedings of the National Academy of Sciences of the United States of America2017
Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
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Who cites it
48 citing papers in PubMed, 83 citations in OpenAlex.
- An Itch Receptor Drives Melanoma.bioRxiv : the preprint server for biology · 2026Article
- Single-Nucleus RNA-Seq Reveals Neuroprotective Effects of Acupuncture in Chronic Migraine Through Modulation of Glial Subtypes.CNS neuroscience & therapeutics · 2026Article
- Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain.Biomolecules · 2026Review
- Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch.Frontiers in molecular neuroscience · 2026Article
- Ectopic engraftment of nociceptive neurons derived from hPSCs for pain relief and joint homeostasis.bioRxiv : the preprint server for biology · 2025Article
- An orally bioavailable MrgprX1-positive allosteric modulator alleviates certain neuropathic pain-related behaviors in humanized mice.Science translational medicine · 2025Article
- Mechanism and modulation of spontaneous pain: from neural circuits to drug development.Molecular biology reports · 2025Review
- Spatial transcriptomics delineates potential differences in intestinal phenotypes of cardiac and classical necrotizing enterocolitis.iScience · 2025Article
- Molecular Glues: A New Approach to Modulating GPCR Signaling Bias.Biochemistry · 2025Review
- Evolutionary scenarios for the specific recognition of nonhomologous endogenous peptides by G protein-coupled receptor paralogs.The Journal of biological chemistry · 2025Article
- Herbomineral Medicine Peedanil Gold Exerts Analgesia in Neuropathy by Moderating Inflammatory Response and TRP Channel Expression in Sprague Dawley Rat Surgical Chronic Constriction Injury Model.Pain research & management · 2025Article
- Article
- Orphan G protein-coupled receptors: the ongoing search for a home.Frontiers in pharmacology · 2024Review
- Targeting sensory neuron GPCRs for peripheral neuropathic pain.Trends in pharmacological sciences · 2023Review
- The Utility of Peripherally Restricted Kappa-Opioid Receptor Agonists for Inhibiting Below-Level Pain After Spinal Cord Injury in Mice.Neuroscience · 2023Article
- Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.Nature communications · 2023Article
- G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics.American journal of physiology. Cell physiology · 2023Review
- Mechanism of agonist-induced activation of the human itch receptor MRGPRX1.PLoS biology · 2023Article
- Scalable mixed model methods for set-based association studies on large-scale categorical data analysis and its application to exome-sequencing data in UK Biobank.American journal of human genetics · 2023Article
- Excitatory and inhibitory neuronal signaling in inflammatory and diabetic neuropathic pain.Molecular medicine (Cambridge, Mass.) · 2023Review
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Zhe LiThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Pang-Yen TsengThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Vinod TiwariDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Qian XuThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Shao-Qiu HeDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Yan WangThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Qin ZhengThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Liang HanThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Zhiping WuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Anna L BlobaumDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Specialized Chemistry Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Yiyuan CuiThe State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Vineeta TiwariDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Shuohao SunThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Yingying ChengThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Julie H Y Huang-LionnetDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Yixun GengThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Bo XiaoThe State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Corey HopkinsDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Specialized Chemistry Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Srinivasa N RajaDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Yun GuanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; xdong2@jhmi.edu yguan1@jhmi.edu.
Xinzhong DongThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; xdong2@jhmi.edu yguan1@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USState Key Laboratory of BiotherapySt. Jude Children's Research Hospital · USVanderbilt University Medical Center · USHoward Hughes Medical Institute · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MMurine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9MFunctional analysis of the Mrg receptor family in pain sensationR01NS054791 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DONG, XINZHONG · 2007 to 2020
$5.0MNeuronal subtype-specific plasticity in the acute to chronic pain transitionR01DE022750 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CATERINA, MICHAEL J, DONG, XINZHONG · 2012 to 2016
$3.5MMrgs as New Target for the Treatment of Neuropathic PainR01NS070814 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2011 to 2020
$3.2MRNA splicing dysfunction in Alzheimer's diseaseR01AG047928 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2015 to 2019
$1.8MMolecular and Cellular Mechanisms of Itch SensationR00NS087088 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAN, LIANG · 2016 to 2018
$739kDeveloping Novel Direct Current Stimulation Technology for Safe Precision Pain TreatmentR21NS099879 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2016 to 2017
$449kHoward Hughes Medical InstituteNCI NIH HHS P30 CA021765NIA NIH HHS R01 AG047928NIDCR NIH HHS R01 DE022750NINDS NIH HHS P30 NS050274NINDS NIH HHS R00 NS087088NINDS NIH HHS R01 NS054791NINDS NIH HHS R01 NS070814NINDS NIH HHS R21 NS099879
Abstract
Human Mas-related G protein-coupled receptor X1 (MRGPRX1) is a promising target for pain inhibition, mainly because of its restricted expression in nociceptors within the peripheral nervous system. However, constrained by species differences across
Indexed as
Disease Models, AnimalAllosteric RegulationAnalgesicsAnimalsBenzamidesCalcium Channel BlockersCalcium ChannelsCattleChronic PainGene ExpressionHumansMaleMiceMice, TransgenicNociceptionPeptide FragmentsAnalgesicsBenzamidesbovine adrenal medulla 8-22Calcium Channel BlockersCalcium Channelsmas-related gene-X1 receptor, humanML382 compoundPeptide FragmentsReceptors, G-Protein-CoupledSulfonamidesDRG neuronsGPCRMrgprX1painpositive allosteric modulator
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.