Evidence map›Paper›PMID 28223511›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase.

Qi Huang, Felicity Alcock, Holger Kneuper, Justin C Deme, Sarah E Rollauer, Susan M Lea, Ben C Berks, Tracy Palmer

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  4. Rational design of a genome-based insulated system inBioengineering & translational medicine · 2023
    Article
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  7. An Engineered Outer Membrane-DefectiveJournal of microbiology and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Qi HuangDivision of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
Felicity AlcockDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Holger KneuperDivision of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
Justin C DemeDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Sarah E RollauerDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Susan M LeaSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.ORCID 0000-0001-9287-8053
Ben C BerksDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Tracy PalmerDivision of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom; t.palmer@dundee.ac.uk.ORCID 0000-0001-9043-2592
University of Oxford · GBUniversity of Dundee · GBNational Institutes of Health · US

Funding

Biotechnology and Biological Sciences Research Council BB/L002531/1Biotechnology and Biological Sciences Research Council BB/N014545/1Medical Research Council G1001640Medical Research Council K000721Medical Research Council MR/L000776/1Wellcome TrustWellcome Trust 107929/Z/15/Z
6 · The paper itself

Abstract

The twin-arginine protein translocation (Tat) system mediates transport of folded proteins across the cytoplasmic membrane of bacteria and the thylakoid membrane of chloroplasts. The Tat system of

Indexed as

Gene Expression Regulation, BacterialProtein Sorting SignalsAmino Acid SequenceAmino Acid SubstitutionArginineBinding SitesEscherichia coliEscherichia coli ProteinsMembrane Transport ProteinsModels, MolecularMutationProtein BindingProtein Conformation, alpha-HelicalProtein FoldingProtein Interaction Domains and MotifsProtein TransportArginineEscherichia coli ProteinsMembrane Transport ProteinsProtein Sorting SignalsTatA protein, E coliTatB protein, E coliTatC protein, E coligenetic suppressorprotein transportTat pathwaytwin arginine signal peptide

Identifiers

PMID28223511
PMCPMC5347605
OpenAlexW2589697056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.