Evidence map›Paper›PMID 28223490›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Sequential activation of the three protomers in the Moloney murine leukemia virus Env.

Mathilda Sjöberg, Robin Löving, Birgitta Lindqvist, Henrik Garoff

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mathilda SjöbergDepartment of Biosciences and Nutrition, Karolinska Institute, S-141 57 Huddinge, Sweden.
Robin LövingDepartment of Biosciences and Nutrition, Karolinska Institute, S-141 57 Huddinge, Sweden.
Birgitta LindqvistDepartment of Biosciences and Nutrition, Karolinska Institute, S-141 57 Huddinge, Sweden.
Henrik GaroffDepartment of Biosciences and Nutrition, Karolinska Institute, S-141 57 Huddinge, Sweden henrik.garoff@ki.se.ORCID 0000-0001-6174-6744
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral membrane fusion proteins of class I are trimers in which the protomeric unit is a complex of a surface subunit (SU) and a fusion active transmembrane subunit (TM). Here we have studied how the protomeric units of Moloney murine leukemia virus envelope protein (Env) are activated in relation to each other, sequentially or simultaneously. We followed the isomerization of the SU-TM disulfide and subsequent SU release from Env with biochemical methods and found that this early activation step occurred sequentially in the three protomers, generating two asymmetric oligomer intermediates according to the scheme (SU-TM)

Indexed as

AlkylationAnimalsCell LineDisulfidesIsomerismMiceMoloney murine leukemia virusProtein SubunitsRatsSurface PropertiesViral Envelope ProteinsViral Fusion ProteinsVirus InternalizationDisulfidesProtein SubunitsViral Envelope ProteinsViral Fusion ProteinsBN-PAGEdisulfide isomeraseintermediateviral membrane fusion

Identifiers

PMID28223490
PMCPMC5347582
OpenAlexW2590039403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.