ArticleProceedings of the National Academy of Sciences of the United States of America2017
Rhythmic brain stimulation reduces anxiety-related behavior in a mouse model based on meditation training.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Non-invasive visual theta entrainment modulates myelin-related and functional outcomes in an LPC-induced demyelination model.PloS one · 2026Article
- Early life adversity and adult attention-deficit/hyperactivity disorder (ADHD): Pathways to persistence and adult susceptibility.Neuroscience and biobehavioral reviews · 2025Review
- Distinct ACC Neural Mechanisms Underlie Authentic and Transmitted Anxiety Induced by Maternal Separation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Structural connectome alterations in anxious dogs: a DTI-based study.Scientific reports · 2023Article
- Beyond Infant's Looking: The Neural Basis for Infant Prediction Errors.Perspectives on psychological science : a journal of the Association for Psychological Science · 2023Review
- Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms.Aging and disease · 2023Article
- Highly unstable heterogeneous representations in VIP interneurons of the anterior cingulate cortex.Molecular psychiatry · 2022Article
- Neuromodulation of cognition in Parkinson's disease.Progress in brain research · 2022Review
- Neurophysiological predictors of gaze-contingent music reward therapy among adults with social anxiety disorder.Journal of psychiatric research · 2021Article
- Endogenous theta stimulation during meditation predicts reduced opioid dosing following treatment with Mindfulness-Oriented Recovery Enhancement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Structural and Functional Hippocampal Correlations in Environmental Enrichment During the Adolescent to Adulthood Transition in Mice.Frontiers in systems neuroscience · 2021Article
- How Early Life Adversity Influences Defensive Circuitry.Trends in neurosciences · 2020Review
- Primer for Mainstreaming Mind-Body Techniques for Extreme Climates-Insights and Future Directions.Medicines (Basel, Switzerland) · 2020Review
- Increasing the amplitude of intrinsic theta in the human brain.AIMS neuroscience · 2020Article
- Frontiers in Pain Research: A Scope of Its Focus and Content.Frontiers in pain research (Lausanne, Switzerland) · 2020Article
- Frontal theta activity and white matter plasticity following mindfulness meditation.Current opinion in psychology · 2019Review
- Restoring Attention Networks.The Yale journal of biology and medicine · 2019Review
- Illuminating the Neural Circuits Underlying Orienting of Attention.Vision (Basel, Switzerland) · 2019Article
- Ancestral Adeno-Associated Virus Vector Delivery of Opsins to Spiral Ganglion Neurons: Implications for Optogenetic Cochlear Implants.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Changes in white matter in mice resulting from low-frequency brain stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meditation training induces changes at both the behavioral and neural levels. A month of meditation training can reduce self-reported anxiety and other dimensions of negative affect. It also can change white matter as measured by diffusion tensor imaging and increase resting-state midline frontal theta activity. The current study tests the hypothesis that imposing rhythms in the mouse anterior cingulate cortex (ACC), by using optogenetics to induce oscillations in activity, can produce behavioral changes. Mice were randomly assigned to groups and were given twenty 30-min sessions of light pulses delivered at 1, 8, or 40 Hz over 4 wk or were assigned to a no-laser control condition. Before and after the month all mice were administered a battery of behavioral tests. In the light/dark box, mice receiving cortical stimulation had more light-side entries, spent more time in the light, and made more vertical rears than mice receiving rhythmic cortical suppression or no manipulation. These effects on light/dark box exploratory behaviors are associated with reduced anxiety and were most pronounced following stimulation at 1 and 8 Hz. No effects were seen related to basic motor behavior or exploration during tests of novel object and location recognition. These data support a relationship between lower-frequency oscillations in the mouse ACC and the expression of anxiety-related behaviors, potentially analogous to effects seen with human practitioners of some forms of meditation.
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