Evidence map›Paper›PMID 28223462›Full record

ArticlemBio2017

Fallacy of the Unique Genome: Sequence Diversity within Single

Jenny L Draper, Lori M Hansen, David L Bernick, Samar Abedrabbo, Jason G Underwood, Nguyet Kong, Bihua C Huang, Allison M Weis, Bart C Weimer, Arnoud H M van Vliet and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. ThemBio · 2025
    Article
  6. Frontiers in cell and developmental biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Journal of bacteriology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Pathogens (Basel, Switzerland) · 2022
    Article
  16. Article
  17. Article
  18. Genome diversity of domesticatedMicrobial genomics · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Jenny L DraperInstitute of Environmental Science and Research, Porirua, New Zealand jenny.draper@esr.cri.nz jvsolnick@ucdavis.edu karplus@soe.ucsc.edu ottemann@ucsc.edu.ORCID 0000-0002-6916-6442
Lori M HansenDepartments of Medicine and Microbiology & Immunology, Center for Comparative Medicine, UC Davis, California, USA.
David L BernickDepartment of Biomolecular Engineering, UC Santa Cruz, Santa Cruz, California, USA.
Samar AbedrabboDepartment of Microbiology & Environmental Toxicology, UC Santa Cruz, Santa Cruz, California, USA.
Jason G UnderwoodPacific Biosciences, Menlo Park, California, USA.
Nguyet KongDepartment of Population Health and Reproduction, 100K Pathogen Genome Project, UC Davis, Davis, California, USA.
Bihua C HuangDepartment of Population Health and Reproduction, 100K Pathogen Genome Project, UC Davis, Davis, California, USA.
Allison M WeisDepartment of Population Health and Reproduction, 100K Pathogen Genome Project, UC Davis, Davis, California, USA.
Bart C WeimerDepartment of Population Health and Reproduction, 100K Pathogen Genome Project, UC Davis, Davis, California, USA.ORCID 0000-0002-7471-1978
Arnoud H M van VlietDepartment of Pathology and Infectious Diseases, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.ORCID 0000-0003-0203-1305
Nader PourmandDepartment of Biomolecular Engineering, UC Santa Cruz, Santa Cruz, California, USA.
Jay V SolnickDepartments of Medicine and Microbiology & Immunology, Center for Comparative Medicine, UC Davis, California, USA jenny.draper@esr.cri.nz jvsolnick@ucdavis.edu karplus@soe.ucsc.edu ottemann@ucsc.edu.
Kevin KarplusDepartment of Biomolecular Engineering, UC Santa Cruz, Santa Cruz, California, USA jenny.draper@esr.cri.nz jvsolnick@ucdavis.edu karplus@soe.ucsc.edu ottemann@ucsc.edu.
Karen M OttemannDepartment of Microbiology & Environmental Toxicology, UC Santa Cruz, Santa Cruz, California, USA jenny.draper@esr.cri.nz jvsolnick@ucdavis.edu karplus@soe.ucsc.edu ottemann@ucsc.edu.ORCID 0000-0001-6265-7401
University of California, Davis · USUniversity of California, Santa Cruz · USPacific Biosciences (United States) · USUniversity of Surrey · GB

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
The function of chemotactic signal transduction during colonization and diseaseR01AI116946 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI OTTEMANN, KAREN M · 2016 to 2025
$5.1M
Roles for Motility in Helicobactor pylori pathogenesisR01AI050000 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI OTTEMANN, KAREN M · 2002 to 2011
$3.6M
Functional Plasticity in the Helicobacter pylori Type IV Secretion SystemR01AI108713 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SOLNICK, JAY V. · 2014 to 2018
$2.9M
NIAID NIH HHS R01 AI050000NIAID NIH HHS R01 AI108713NIAID NIH HHS R01 AI116946NIH HHS P51 OD011107
6 · The paper itself

Abstract

Many bacterial genomes are highly variable but nonetheless are typically published as a single assembled genome. Experiments tracking bacterial genome evolution have not looked at the variation present at a given point in time. Here, we analyzed the mouse-passaged

Indexed as

Genetic VariationGenome, BacterialAnimalsHelicobacter pyloriHigh-Throughput Nucleotide SequencingMiceMutation

Identifiers

PMID28223462
PMCPMC5358919
OpenAlexW2590570350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.