Evidence map›Paper›PMID 28223431›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2017

Changes in the Glycosylation of Kininogen and the Development of a Kininogen-Based Algorithm for the Early Detection of HCC.

Mengjun Wang, Miloslav Sanda, Mary Ann Comunale, Harmin Herrera, Charles Swindell, Yuko Kono, Amit G Singal, Jorge Marrero, Timothy Block, Radoslav Goldman and 1 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03878550 (Case-Control Study of the Glycotest™ HCC Panel Vs AFP for the Detection of Early-stage Hepatocellular Carcinoma), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03878550 active not recruitingnot on this mapstarted 2019, after this paper: background citation

Case-Control Study of the Glycotest™ HCC Panel Vs AFP for the Detection of Early-stage Hepatocellular Carcinoma

TypeobservationalSponsorGlycotest, Inc.Ran2019 to 2025Enrolled766ConditionsCarcinoma, Hepatocellular, Cirrhosis, Liver
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Hepatocellular Carcinoma: The Search for an Optimal Screening Test.Middle East journal of digestive diseases · 2025
    Review
  6. Article
  7. Article
  8. Alpha-fetoprotein: Past, present, and future.Hepatology communications · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Doylestown Plus and GALAD Demonstrate High Sensitivity for HCC Detection in Patients With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Mengjun WangDepartment of Cell and Molecular Pharmacology, Medical University of South Carolina, Medical University of South Carolina, Charleston, South Carolina.
Miloslav SandaDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.
Mary Ann ComunaleDepartment of Microbiology and Immunology, Drexel University, Philadelphia, Pennsylvania.
Harmin HerreraDepartment of Microbiology and Immunology, Drexel University, Philadelphia, Pennsylvania.
Charles SwindellGlycotest, Inc, New York, New York.
Yuko KonoDivision of Gastroenterology and Hepatology, University of California, San Diego, California.
Amit G SingalDivision of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, Texas.
Jorge MarreroDivision of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, Texas.
Timothy BlockThe Baruch S. Blumberg Institute, Doylestown, Pennsylvania.
Radoslav GoldmanDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.
Anand MehtaDepartment of Cell and Molecular Pharmacology, Medical University of South Carolina, Medical University of South Carolina, Charleston, South Carolina. mehtaa@musc.edu.
Drexel University · USGeorgetown University · USMedical University of South Carolina · USThe University of Texas Southwestern Medical Center · USBaruch S. Blumberg Institute · USStantec (United States) · USUniversity of California System · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
Predicting HCC through GlycomicsR01CA120206 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MEHTA, ANAND S. · 2006 to 2016
$4.3M
Glycans in Hepatocellular CarcinomaR01CA135069 · NCI · GEORGETOWN UNIVERSITY · PI GOLDMAN, RADOSLAV · 2009 to 2019
$4.1M
Alliance of Glycobiologists for Detection of CancerU01CA168926 · NCI · GEORGETOWN UNIVERSITY · PI GOLDMAN, RADOSLAV · 2012 to 2016
$2.0M
Aberrantly secreted glycoproteins as markers of liver cancerU01CA168856 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MEHTA, ANAND S. · 2012 to 2016
$1.5M
Basic Cancer Research in Cancer Health DisparitiesU01CA171146 · NCI · GEORGETOWN UNIVERSITY · PI GOLDMAN, RADOSLAV · 2012 to 2016
$1.5M
5600 TripleTOF Mass SpectrometryS10OD016441 · OD · GEORGETOWN UNIVERSITY · PI GOLDMAN, RADOSLAV · 2013 to 2013
$381k
NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA120206NCI NIH HHS R01 CA135069NCI NIH HHS U01 CA168856NCI NIH HHS U01 CA168926NCI NIH HHS U01 CA171146NIH HHS S10 OD016441
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AlgorithmsAgedalpha-FetoproteinsBiomarkers, TumorCarcinoma, HepatocellularEarly Detection of CancerFemaleHumansKininogensLiver NeoplasmsMaleMiddle AgedSensitivity and SpecificityUnited Statesalpha-FetoproteinsBiomarkers, TumorKininogensKNG1 protein, human

Identifiers

PMID28223431
PMCPMC5759760
OpenAlexW2589695754

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.