Evidence map›Paper›PMID 28223384›Full record

ArticleAntimicrobial agents and chemotherapy2017

Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of

Feng Yang, Lulu Zhang, Hironao Wakabayashi, Jason Myers, Yuanying Jiang, Yongbing Cao, Cristina Jimenez-Ortigosa, David S Perlin, Elena Rustchenko

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Microbiology and molecular biology reviews : MMBR · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Echinocandin Adaptation inJournal of fungi (Basel, Switzerland) · 2025
    Article
  10. Review
  11. Caspofungin paradoxical growth inFrontiers in cellular and infection microbiology · 2025
    Article
  12. Disruption tomSphere · 2024
    Article
  13. Review
  14. Review
  15. Journal of fungi (Basel, Switzerland) · 2024
    Article
  16. Article
  17. Aneuploidy underlies brefeldin A-induced antifungal drug resistance inFrontiers in cellular and infection microbiology · 2024
    Article
  18. Article
  19. Review
  20. eLife · 2023
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Feng YangDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, USA.
Lulu ZhangCenter for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
Hironao WakabayashiDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, USA.
Jason MyersGenomic Research Center, University of Rochester Medical Center, Rochester, New York, USA.
Yuanying JiangCenter for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
Yongbing CaoCenter for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China ybcao@vip.sina.com elena_bulgac@urmc.rochester.edu.
Cristina Jimenez-OrtigosaPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
David S PerlinPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Elena RustchenkoDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, USA ybcao@vip.sina.com elena_bulgac@urmc.rochester.edu.
University of Rochester Medical Center · USSecond Military Medical University · CNRutgers HealthRutgers, The State University of New Jersey · US

Funding

Critical Factors Influencing Echinocandin Resistance in CandidaglabrataR01AI109025 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PERLIN, DAVID S · 2014 to 2025
$9.8M
Molecular mechanisms of caspofungin resistance in the pathogen Candida albicansR01AI110764 · NIAID · UNIVERSITY OF ROCHESTER · PI RUSTCHENKO, ELENA · 2014 to 2016
$1.0M
NIAID NIH HHS R01 AI109025NIAID NIH HHS R01 AI110764
6 · The paper itself

Abstract

Expanding echinocandin use to prevent or treat invasive fungal infections has led to an increase in the number of breakthrough infections due to resistant

Indexed as

Antifungal Agentsbeta-GlucansCalcineurinCandida albicansCaspofunginCell WallChitinChitinasesDrug Resistance, FungalEchinocandinsHumansLipopeptidesMembrane GlycoproteinsMicrobial Sensitivity TestsAntifungal Agentsbeta-GlucansCalcineurinCaspofunginChitinChitinasesEchinocandinsLipopeptidesMembrane GlycoproteinsCandida albicanscaspofungin tolerancechromosome 5molecular mechanisms

Identifiers

PMID28223384
PMCPMC5404545
OpenAlexW2590904034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.