Evidence map›Paper›PMID 28223383›Full record

ArticleAntimicrobial agents and chemotherapy2017

Requirement of the CroRS Two-Component System for Resistance to Cell Wall-Targeting Antimicrobials in Enterococcus faecium.

Stephanie L Kellogg, Jaime L Little, Jessica S Hoff, Christopher J Kristich

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 61 citations in OpenAlex.

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  19. Insights into Kinases of ESKAPE Pathogens for Therapeutic Interventions.Cardiovascular & hematological agents in medicinal chemistry · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Stephanie L KelloggDepartment of Microbiology and Immunology, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jaime L LittleDepartment of Microbiology and Immunology, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jessica S HoffDepartment of Microbiology and Immunology, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Christopher J KristichDepartment of Microbiology and Immunology, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA ckristich@mcw.edu.
Medical College of Wisconsin · US

Funding

Genetic approaches to protein-protein interactions mediating antibiotic resistancDP2OD006447 · OD · MEDICAL COLLEGE OF WISCONSIN · PI KRISTICH, CHRISTOPHER J · 2009 to 2009
$2.3M
Intrinsic Resistance to antimicrobials in Enterococcus faecalisR01AI081692 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI KRISTICH, CHRISTOPHER J · 2010 to 2014
$1.9M
NIAID NIH HHS R01 AI081692NIH HHS DP2 OD006447
6 · The paper itself

Abstract

Enterococci are serious opportunistic pathogens that are resistant to many cell wall-targeting antibiotics. The CroRS two-component signaling system responds to antibiotic-mediated cell wall stress and is critical for resistance to cell wall-targeting antibiotics in

Indexed as

Amino Acid SequenceAmpicillinAnti-Bacterial AgentsBacitracinBacterial Proteinsbeta-Lactam ResistanceCell WallCephalosporinsEnterococcus faecalisEnterococcus faeciumGene DeletionMicrobial Sensitivity TestsProtein KinasesSignal TransductionTrans-ActivatorsVancomycinAmpicillinAnti-Bacterial AgentsBacitracinBacterial ProteinsCephalosporinsProtein KinasesTrans-ActivatorsVancomycinantibiotic resistanceenterococcustwo-component regulatory systems

Identifiers

PMID28223383
PMCPMC5404561
OpenAlexW2589391918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.