Evidence map›Paper›PMID 28223375›Full record

ArticleAntimicrobial agents and chemotherapy2017

The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation.

Emily Larkin, Christopher Hager, Jyotsna Chandra, Pranab K Mukherjee, Mauricio Retuerto, Iman Salem, Lisa Long, Nancy Isham, Laura Kovanda, Katyna Borroto-Esoda and 3 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03363841 (Open-Label Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Oral Ibrexafungerp), which is not on this map. Cited by 200 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 1 pooled it
32.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03363841 phase3completednot on this map

Open-Label Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Oral Ibrexafungerp (SCY-078) as an Emergency Use Treatment for Patients With Candidiasis, Including Candidemia, Caused by Candida Auris

TypeinterventionalSponsorScynexis, Inc.Ran2017 to 2023Enrolled30ConditionsCandidiasis, Invasive, CandidemiaArmsSCY-078
3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 1 synthesis or guideline pooled it, 382 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Pharmacological advances inJournal of enzyme inhibition and medicinal chemistry · 2026
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  5. Disinfectant tolerance ofMicrobiology spectrum · 2026
    Article
  6. In Vitro Acid Resistance of Feline-DerivedJournal of fungi (Basel, Switzerland) · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Journal of fungi (Basel, Switzerland) · 2026
    Review
  12. Mortality ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  13. UnderstandingJournal of medical microbiology · 2026
    Review
  14. Review
  15. Review
  16. Prevalence, pattern of disease and antimicrobial susceptibility ofSouthern African journal of infectious diseases · 2026
    Article
  17. StudyingPharmaceuticals (Basel, Switzerland) · 2025
    Review
  18. Article
  19. Repositioning Antimicrobial Peptides Against WHO-Priority Fungi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  20. Article

140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Emily LarkinCenter for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Christopher HagerCenter for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Jyotsna ChandraCenter for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Pranab K MukherjeeCenter for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Mauricio RetuertoCenter for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Iman SalemCenter for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Lisa LongCenter for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Nancy IshamCenter for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Laura KovandaAstellas Pharma Global Development, Inc., Northbrook, Illinois, USA.ORCID 0000-0002-4493-4652
Katyna Borroto-EsodaScynexis Inc., Jersey City, New Jersey, USA.
Steve WringScynexis Inc., Jersey City, New Jersey, USA.
David AnguloScynexis Inc., Jersey City, New Jersey, USA.
Mahmoud GhannoumCenter for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA Mahmoud.Ghannoum@Case.edu.
University Hospitals of Cleveland · USScynexis (United States) · USAstellas Pharma (United States) · US

Funding

Vitamin D endocrine system and Protection Against Skin TumorlgenesisP30AR039750 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1988 to 2015
$9.1M
Mechanism of antifungal action of Pichia proteinsR01DE024228 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI GHANNOUM, MAHMOUD A · 2014 to 2018
$2.0M
NIAMS NIH HHS P30 AR039750NIDCR NIH HHS R01 DE024228
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amphotericin BAntifungal AgentsBiofilmsCandidaCandida albicansCandidiasisCell AdhesionCell DivisionDrug Resistance, Multiple, FungalFluconazoleGlucansGlycosidesHumansMicrobial Sensitivity TestsPeptide HydrolasesPhospholipasesAmphotericin BAntifungal AgentsFluconazoleGlucansGlycosidesibrexafungerpPeptide HydrolasesPhospholipasesTriterpenesVirulence FactorsbiofilmCandida aurisSCY-078virulence

Identifiers

PMID28223375
PMCPMC5404565
OpenAlexW2589939125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.