Evidence map›Paper›PMID 28223145›Full record

ArticleBehavioural brain research2017

Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine.

Bryan F Singer, Myranda A Bryan, Pavlo Popov, Terry E Robinson, Brandon J Aragona

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bryan F SingerBiopsychology Area, Department of Psychology, University of Michigan, 530 Church Street, East Hall, Ann Arbor, MI 48109, USA. Electronic address: bfsinger@umich.edu.
Myranda A BryanBiopsychology Area, Department of Psychology, University of Michigan, 530 Church Street, East Hall, Ann Arbor, MI 48109, USA.
Pavlo PopovBiopsychology Area, Department of Psychology, University of Michigan, 530 Church Street, East Hall, Ann Arbor, MI 48109, USA.
Terry E RobinsonBiopsychology Area, Department of Psychology, University of Michigan, 530 Church Street, East Hall, Ann Arbor, MI 48109, USA.
Brandon J AragonaBiopsychology Area, Department of Psychology, University of Michigan, 530 Church Street, East Hall, Ann Arbor, MI 48109, USA.
University of Michigan–Ann Arbor · US

Funding

POSTDOCTORAL TRAINING IN THE BIOLOGY OF DRUG ABUSET32DA007268 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 1991 to 2021
$6.7M
Variation in Motivational Properties of Reward Cues: Implications for AddictionP01DA031656 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBINSON, TERRY E. · 2012 to 2016
$6.3M
Individual Variation in Dopamine Encoding of Incentive SalienceF32DA038383 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SINGER, BRYAN FREDERICK · 2014 to 2015
$81k
NIDA NIH HHS F32 DA038383NIDA NIH HHS P01 DA031656NIDA NIH HHS T32 DA007268
6 · The paper itself

Abstract

Repeated intermittent exposure to cocaine results in the neurochemical sensitization of dopamine (DA) transmission within the nucleus accumbens (NAc). Indeed, the excitability of DA neurons in the ventral tegmental area (VTA) is enhanced within hours of initial psychostimulant exposure. However, it is not known if this is accompanied by a comparably rapid change in the ability of cocaine to increase extracellular DA concentrations in the ventral striatum. To address this question we used fast-scan cyclic voltammetry (FSCV) in awake-behaving rats to measure DA responses in the NAc shell following an initial intravenous cocaine injection, and then again 2-h later. Both injections quickly elevated DA levels in the NAc shell, but the second cocaine infusion produced a greater effect than the first, indicating sensitization. This suggests that a single injection of cocaine induces sensitization-related plasticity very rapidly within the mesolimbic DA system.

Indexed as

AnimalsCocaineDopamineMaleNeuronal PlasticityNucleus AccumbensRats, Sprague-DawleyVentral Tegmental AreaCocaineDopamineCocaineDopamineNucleus accumbensPsychostimulantSensitizationVoltammetry

Identifiers

PMID28223145
PMCPMC5346451
OpenAlexW2588268045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.