Evidence map›Paper›PMID 28223033›Full record

ArticleDevelopmental cognitive neuroscience2018

Children with ASD show links between aberrant sound processing, social symptoms, and atypical auditory interhemispheric and thalamocortical functional connectivity.

Annika C Linke, R Joanne Jao Keehn, Ellyn B Pueschel, Inna Fishman, Ralph-Axel Müller

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
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  8. Review
  9. Atypical Postural Control Variability and Coordination Persist Into Middle and Older Adulthood in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025
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  20. Increased resting-state thalamocortical functional connectivity in children and young adults with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Annika C LinkeBrain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado CT, Suite #200, San Diego, CA, 92120, USA. Electronic address: alinke@mail.sdsu.edu.
R Joanne Jao KeehnBrain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado CT, Suite #200, San Diego, CA, 92120, USA. Electronic address: rjao@mail.sdsu.edu.
Ellyn B PueschelBrain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado CT, Suite #200, San Diego, CA, 92120, USA.
Inna FishmanBrain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado CT, Suite #200, San Diego, CA, 92120, USA.
Ralph-Axel MüllerBrain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado CT, Suite #200, San Diego, CA, 92120, USA.
San Diego State University · US

Funding

Integrity and Dynamic Processing Efficiency of Networks in ASDR01MH101173 · NIMH · SAN DIEGO STATE UNIVERSITY · PI MUELLER, RALPH-AXEL · 2014 to 2018
$3.2M
Linking Local Activity and Functional Connectivity in AutismR01MH081023 · NIMH · SAN DIEGO STATE UNIVERSITY · PI MUELLER, RALPH-AXEL · 2009 to 2013
$1.9M
Multimodal Imaging of Social Brain Networks in ASDK01MH097972 · NIMH · SAN DIEGO STATE UNIVERSITY · PI FISHMAN, INNA · 2012 to 2015
$599k
NIMH NIH HHS K01 MH097972NIMH NIH HHS R01 MH081023NIMH NIH HHS R01 MH101173
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a complex and prevalent neurodevelopmental disorder characterized by social and communicative deficits, as well as repetitive behaviors and atypical sensitivity to sensory stimulation. Alterations in network connectivity are widely recognized, but their interplay with social and sensory symptoms remains largely unclear. Here, functional magnetic resonance imaging and diagnostic and behavioral assessments were used in a cohort of children and adolescents with ASD (n=40) and matched typically developing (TD, n=38) controls to examine the relation between auditory processing, interhemispheric and thalamocortical network connectivity, and social-behavioral symptom severity. We found that atypical processing of sounds was related to social, cognitive, and communicative impairments. Additionally, severity of sensory processing deficits and lower verbal IQ were related to reduced interhemispheric connectivity of auditory cortices in ASD. Increased connectivity between the thalamus and auditory cortex in ASD, however, was associated with reduced cognitive and behavioral symptomatology, suggesting that thalamocortical overconnectivity might reflect a compensatory mechanism in ASD. These findings provide novel evidence for links between auditory sensory deficits and impairments in social interaction and communication.

Indexed as

Auditory PerceptionSocial BehaviorAdolescentAuditory CortexAutism Spectrum DisorderChildCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleThalamusAuditoryAutism spectrum disorderCorpus callosumfMRIFunctional connectivityThalamus

Identifiers

PMID28223033
PMCPMC5664206
OpenAlexW2571969900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.