Evidence map›Paper›PMID 28223004›Full record

ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017

Sudden Cardiac Death Among Hemodialysis Patients.

Melissa S Makar, Patrick H Pun

Abstract readCase ReportsReview
In one paragraph

Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Mineralocorticoid Receptor Antagonists in Dialysis.American journal of nephrology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Observational
  12. Observational
  13. Cardiac Arrest in Outpatient Hemodialysis Units: A National Cross-Sectional Survey of Dialysis Technicians.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Article
  14. Observational
  15. Article
  16. Article
  17. Review
  18. Article
  19. Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Melissa S MakarDuke Clinical Research Institute, Durham, NC; Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC. Electronic address: melissa.makar@duke.edu.
Patrick H PunDuke Clinical Research Institute, Durham, NC; Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC.
Clinical Research Institute · US

Funding

Renal Genomics CoreP30DK096493 · NIDDK · DUKE UNIVERSITY · PI WINN, MICHELLE P. · 2012 to 2016
$5.9M
DUKE TRAINING GRANT IN NEPHROLOGYT32DK007731 · NIDDK · DUKE UNIVERSITY · PI CROWLEY, STEVEN D · 1995 to 2021
$3.6M
Risk Factors for Sudden Cardiac Death in Patients with Chronic Kidney DiseaseK23DK098281 · NIDDK · DUKE UNIVERSITY · PI PUN, PATRICK H · 2014 to 2016
$439k
NIDDK NIH HHS K23 DK098281NIDDK NIH HHS P30 DK096493NIDDK NIH HHS T32 DK007731
6 · The paper itself

Abstract

Hemodialysis patients carry a large burden of cardiovascular disease; most onerous is the high risk for sudden cardiac death. Defining sudden cardiac death among hemodialysis patients and understanding its pathogenesis are challenging, but inferences from the existing literature reveal differences between sudden cardiac death among hemodialysis patients and the general population. Vascular calcifications and left ventricular hypertrophy may play a role in the pathophysiology of sudden cardiac death, whereas traditional cardiovascular risk factors seem to have a more muted effect. Arrhythmic triggers also differ in this group as compared to the general population, with some arising uniquely from the hemodialysis procedure. Combined, these factors may alter the types of terminal arrhythmias that lead to sudden cardiac death among hemodialysis patients, having important implications for prevention strategies. This review highlights current knowledge on the epidemiology, pathophysiology, and risk factors for sudden cardiac death among hemodialysis patients. We then examine strategies for prevention, including the use of specific cardiac medications and device-based therapies such as implantable defibrillators. We also discuss dialysis-specific prevention strategies, including minimizing exposure to low potassium and calcium dialysate concentrations, extending dialysis treatment times or adding sessions to avoid rapid ultrafiltration, and lowering dialysate temperature.

Indexed as

AdultArrhythmias, CardiacCalciumDeath, Sudden, CardiacDefibrillators, ImplantableHemodialysis SolutionsHumansHypertrophy, Left VentricularKidney Failure, ChronicMalePotassiumRenal DialysisRisk FactorsVascular CalcificationCalciumHemodialysis SolutionsPotassiumarrhythmiadialysisend-stage kidney diseaseend-stage renal disease (ESRD)hemodialysispathogenesispathophysiologypreventionprevention strategiesreviewrisk factorsSudden cardiac death (SCD)sudden death

Identifiers

PMID28223004
PMCPMC5457912
OpenAlexW2589011199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.