ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017
Rethinking CKD Evaluation: Should We Be Quantifying Basal or Stimulated GFR to Maximize Precision and Sensitivity?
Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- A Novel Method for Rapid Bedside Measurement of GFR.Journal of the American Society of Nephrology : JASN · 2018Trial
- Evaluation of serum galectin-3 concentrations in healthy cats and in cats with ureteral obstruction.Journal of feline medicine and surgery · 2025Article
- Challenges of Serum Creatinine Level in GFR Assessment and Drug Dosing Decisions in Kidney Injury.Advanced pharmaceutical bulletin · 2024Review
- Impaired hemodynamic renal reserve response following recovery from established acute kidney injury and improvement by hydrodynamic isotonic fluid delivery.American journal of physiology. Renal physiology · 2024Article
- Hemodynamic Renal Reserve Response in Conscious Normotensive and Hypertensive Mice.Kidney & blood pressure research · 2024Article
- Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon.Cureus · 2023Review
- DNA damage response protects against progressive kidney disease.The Journal of clinical investigation · 2019Article
- Estimating GFR in the Elderly-New Approaches to an Old Problem.Kidney international reports · 2019Article
- Subclinical AKI: ready for primetime in clinical practice?Journal of nephrology · 2019Review
- Haemodynamic or metabolic stimulation tests to reveal the renal functional response: requiem or revival?Clinical kidney journal · 2018Article
- Augmented renal clearance.Translational and clinical pharmacology · 2018Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Chronic kidney disease (CKD) is an increasing clinical problem. Although clinical risk factors and biomarkers for the development and progression of CKD have been identified, there is no commercial surveillance technology to definitively diagnose and quantify the severity and progressive loss of glomerular filtration rate (GFR) in CKD. This has limited the study of potential therapies to late stages of CKD when FDA-registerable events are more likely. Because patient outcomes, including the rate of CKD progression, correlate with disease severity and effective therapy may require early intervention, being able to diagnose and stratify patients by their level of decreased kidney function early on is key for translational progress. In addition, renal reserve, defined as the increase in GFR following stimulation, may improve the quantification of GFR based solely on basal levels. Various groups are developing and characterizing optical measurement techniques using new minimally invasive or noninvasive approaches for quantifying basal and stimulated kidney function. This development has the potential to allow widespread individualization of therapy at an earlier disease stage. Therefore, the purposes of this review are to suggest why quantifying stimulated GFR, by activating renal reserve, may be advantageous in patients and to review fluorescent technologies to deliver patient-specific GFR.
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Registered trials
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