Evidence map›Paper›PMID 28222855›Full record

ArticleSurgery2017

Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism.

Andrea Schmidt, James Sinnett-Smith, Steven Young, Hui-Hua Chang, O Joe Hines, David W Dawson, Enrique Rozengurt, Guido Eibl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Andrea SchmidtDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum Freiburg, Freiburg, Germany.
James Sinnett-SmithDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Steven YoungDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Hui-Hua ChangDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
O Joe HinesDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
David W DawsonDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Enrique RozengurtDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Guido EiblDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address: GEibl@mednet.ucla.edu.
University of California, Los Angeles · USUniversity Medical Center Freiburg · DE

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2012 to 2016
$6.2M
PKD1 Signaling and Crosstalk Mechanisms in Intestinal Epithelial Cell RegulationR01DK100405 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 2014 to 2017
$1.3M
NCI NIH HHS P01 CA163200NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK100405
6 · The paper itself

Abstract

backgroundThere is strong evidence linking inflammation and the development of pancreatic ductal adenocarcinoma. Cyclooxygenase-2 (COX-2) and COX-2-derived PGE

methodsHuman pancreatic ductal adenocarcinoma cell lines, Panc-1 and MIA PaCa-2, were treated with PGE

resultsPGE

conclusionOur study provides evidence that PGE

Indexed as

AgedBlotting, WesternCarcinoma, Pancreatic DuctalCell Line, TumorCell ProliferationCyclooxygenase 2DinoprostoneFemaleGene Expression RegulationHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedPancreasPancreatic NeoplasmsPhosphorylationCyclooxygenase 2DinoprostoneIntracellular Signaling Peptides and Proteinsprotein kinase modulatorPTGER1 protein, humanReceptors, Prostaglandin E, EP1 SubtypeReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 Subtype

Identifiers

PMID28222855
PMCPMC5433907
OpenAlexW2590274711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.