Presumptive Spontaneous Lysosomal Storage-Like Disease in a Crl:CD1(ICR) Mouse.

Krista M Hernon, Tiffany L Whitcomb, Lori Davis, Timothy K Cooper

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In one paragraph

Article in Comparative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 72% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Krista M HernonDepartment of Comparative Medicine, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, Preclinical Health, Allegheny Health Network Research Institute, Allegheny Health Network, Pittsburgh, Pennsylvania.

Tiffany L WhitcombDepartment of Comparative Medicine, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania.

Lori DavisDepartment of Comparative Medicine, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania.

Timothy K CooperDepartment of Comparative Medicine, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, Charles River Laboratories - Contractor Supporting National Institute of Allergy and Infectious Diseases (NIAID), Fort Detrick, Maryland;, Email: tcooper@hmc.psu.edu.

Penn State Milton S. Hershey Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A clinically unremarkable 4.5-mo-old female Crl:CD1(ICR) VAF/Elite mouse was euthanized for scheduled sentinel processing. Gross necropsy findings included significant hepatosplenomegaly and visceral lymphadenomegaly, resulting in a preliminary gross diagnosis of lymphoma. Histology revealed florid accumulations of large, 'foamy' macrophages present in the bone marrow, small intestines, and viscera including liver, spleen, lymph nodes, thymus, uterus, and ovaries. The cytoplasm of these cells was abundant, stained pale blue with Wright-Giemsa and was periodic acid-Schiff positive. Given these characteristic gross and histologic findings, a spontaneous lysosomal storage-like disease was diagnosed in this mouse. Cholesterol ester storage disease is likely, because of the visceral involvement with sparing of the CNS, but could not be diagnosed definitively. To our knowledge, this report is the first to describe a case of spontaneous lysosomal storage disease in an outbred mouse of the CD1(ICR) background.

Indexed as

AnimalsFemaleLiverLymphadenopathyLymph NodesLysosomal Storage DiseasesMiceMice, Inbred ICRMutationSpleenSplenomegaly

Identifiers

PMID28222836

PMCPMC5310622

OpenAlexW2903338138

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.