Evidence map›Paper›PMID 28222775›Full record

ArticleBreast cancer research : BCR2017

Modification of the association between recreational physical activity and survival after breast cancer by promoter methylation in breast cancer-related genes.

Lauren E McCullough, Jia Chen, Yoon Hee Cho, Nikhil K Khankari, Patrick T Bradshaw, Alexandra J White, Susan L Teitelbaum, Mary Beth Terry, Alfred I Neugut, Hanina Hibshoosh and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Lauren E McCulloughDepartment of Epidemiology, Emory University, Atlanta, GA, 30322, USA. lauren.mccullough@emory.edu.
Jia ChenDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Yoon Hee ChoDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, 59812, USA.
Nikhil K KhankariDivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Patrick T BradshawDivision of Epidemiology, University of California Berkeley, Berkeley, CA, 94720, USA.
Alexandra J WhiteEpidemiology Branch, National Institute of Environmental Health Science, Research Triangle Park, NC, 27709, USA.
Susan L TeitelbaumDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Mary Beth TerryDepartment of Epidemiology, Columbia University, New York, NY, 10032, USA.
Alfred I NeugutDepartment of Epidemiology, Columbia University, New York, NY, 10032, USA.
Hanina HibshooshDepartment of Pathology, Columbia University, New York, NY, 10032, USA.
Regina M SantellaDepartment of Environmental Health Sciences, Columbia University, New York, NY, 10032, USA.
Marilie D GammonDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Columbia University · USIcahn School of Medicine at Mount Sinai · USEmory University · USTriangle · USUniversity of California, Berkeley · USUniversity of Montana · USUniversity of North Carolina at Chapel Hill · USVanderbilt University Medical Center · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3M
LINEBERGER CANCER CONTROL EDUCATION PROGRAMR25CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EARP, JO ANNE L, RIBISL, KURT M. · 1992 to 2016
$8.0M
Cancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7M
Dietary Methyl Content, Epigenetics and Breast CancerR01CA109753 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHEN, JIA · 2006 to 2010
$2.9M
NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA109753NCI NIH HHS R25 CA057726NCI NIH HHS T32 CA057726NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES023515
6 · The paper itself

Abstract

backgroundMechanisms underlying the inverse association between physical activity and survival after breast cancer are unresolved, but DNA methylation may play a role. We hypothesized that promoter methylation of breast cancer-related genes, as well as global methylation, may modify the association between prediagnostic recreational physical activity (RPA) and breast cancer mortality.

methodsUsing a population-based sample of 1254 women diagnosed with first primary breast cancer, we examined modification of the RPA-mortality association by gene-specific promoter methylation and global methylation. Average lifetime RPA was assessed from menarche to diagnosis through structured in-home interviews. Promoter methylation of 13 breast cancer-related genes was evaluated in archived tumor by methylation-specific polymerase chain reaction and MethyLight assay. Global methylation in white blood cell DNA was determined at long interspersed nucleotide element 1 and by the luminometric methylation assay. After approximately 15 years of follow-up, 486 patients had died, and 186 of the deaths were breast cancer-related. We used Cox proportional hazards regression to estimate HRs and 95% CIs as well as likelihood ratio tests to assess multiplicative interactions.

resultsAll-cause mortality was lower only among physically active women with methylated promoter of APC (HR 0.60, 95% CI 0.40-0.80), CCND2 (HR 0.56, 95% CI 0.32-0.99), HIN (HR 0.55, 95% CI 0.38-0.80), and TWIST1 (HR 0.28, 95% CI 0.14-0.56) in tumors, but not among those with unmethylated tumors (significant interaction p < 0.05). We found no interaction between RPA and global methylation.

conclusionsThe improved survival after breast cancer that is associated with RPA may be more pronounced in women with promoter tumor methylation in biologically plausible genes.

Indexed as

DNA MethylationExerciseOncogenesPopulation SurveillancePromoter Regions, GeneticAdultAgedBreast NeoplasmsCombined Modality TherapyFemaleHumansMiddle AgedMortalityNew YorkPrognosisRecreationBreast cancerEpigeneticsMethylationPhysical activitySurvival

Identifiers

PMID28222775
PMCPMC5319077
OpenAlexW2590541801

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.