Evidence map›Paper›PMID 28222761›Full record

ArticleMicrobiome2017

New evidences on the altered gut microbiota in autism spectrum disorders.

Francesco Strati, Duccio Cavalieri, Davide Albanese, Claudio De Felice, Claudio Donati, Joussef Hayek, Olivier Jousson, Silvia Leoncini, Daniela Renzi, Antonio Calabrò and 1 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 528 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
528citing papers in PubMed, 11 pooled it
36.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06200935 completednot on this mapstarted 2021, after this paper: background citation

Results of the Action of a Combination of Probiotics on the Microbiota and Intestinal Permeability in Children With Neurodevelopmental Disorders and Their Influence on the Improvement of Language, Behavioral Evolution and Learning

TypeobservationalSponsorInstituto de Genética Médica y MolecularRan2021 to 2022Enrolled90ConditionsNeurodevelopmental DisordersArmsProbiotic blend
NCT06290258 phase1 / phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Fecal Microbiota Transplantation for Gastrointestinal, Autistic, Emotion, and Behavior Symptoms of Patients With Autism Spectrum Disorder and Gastrointestinal Problems: a Preliminary Study.

TypeinterventionalSponsorChang Gung Memorial HospitalRan2024 to 2027Enrolled60ConditionsAutism Spectrum Disorder, Gastrointestinal Diseases, HealthyArmsFecal microbiota transplantation
3 · Its place in the literature

Who cites it

528 citing papers in PubMed, 11 syntheses or guidelines pooled it, 1,029 citations in OpenAlex.

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  10. Microbiota in Autism Spectrum Disorder: A Systematic Review.International journal of molecular sciences · 2023
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  17. mSphere · 2026
    Article
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468 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Francesco StratiComputational Biology Research Unit, Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38010, San Michele all' Adige, Italy.
Duccio CavalieriDepartment of Biology, University of Florence, Via Madonna del Piano 6, 50019, Sesto Fiorentino, Florence, Italy.
Davide AlbaneseComputational Biology Research Unit, Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38010, San Michele all' Adige, Italy.
Claudio De FeliceNeonatal Intensive Care Unit, Siena University Hospital AOUS, Viale Bracci 16, 53100, Siena, Italy.
Claudio DonatiComputational Biology Research Unit, Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38010, San Michele all' Adige, Italy.
Joussef HayekChild Neuropsychiatry Unit, Siena University Hospital AOUS, Viale Bracci 16, 53100, Siena, Italy.
Olivier JoussonCentre for Integrative Biology, University of Trento, Via Sommarive 9, 38123, Trento, Italy.
Silvia LeonciniChild Neuropsychiatry Unit, Siena University Hospital AOUS, Viale Bracci 16, 53100, Siena, Italy.
Daniela RenziDepartment of Experimental and Clinical Biomedical Sciences, Gastroenterology Unit, University of Florence, Viale Morgagni 40, 50139, Florence, Italy.
Antonio CalabròDepartment of Experimental and Clinical Biomedical Sciences, Gastroenterology Unit, University of Florence, Viale Morgagni 40, 50139, Florence, Italy.
Carlotta De FilippoInstitute of Agriculture Biology and Biotechnology, National Research Council (CNR), Via Moruzzi 1, 56124, Pisa, Italy. carlotta.defilippo@ibba.cnr.it.
University of Florence · ITFondazione Edmund Mach · ITUniversity of Siena · ITUniversity of Trento · ITASL Roma · ITNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutism spectrum disorders (ASDs) are neurodevelopmental conditions characterized by social and behavioural impairments. In addition to neurological symptoms, ASD subjects frequently suffer from gastrointestinal abnormalities, thus implying a role of the gut microbiota in ASD gastrointestinal pathophysiology.

resultsHere, we characterized the bacterial and fungal gut microbiota in a cohort of autistic individuals demonstrating the presence of an altered microbial community structure. A fraction of 90% of the autistic subjects were classified as severe ASDs. We found a significant increase in the Firmicutes/Bacteroidetes ratio in autistic subjects due to a reduction of the Bacteroidetes relative abundance. At the genus level, we observed a decrease in the relative abundance of Alistipes, Bilophila, Dialister, Parabacteroides, and Veillonella in the ASD cohort, while Collinsella, Corynebacterium, Dorea, and Lactobacillus were significantly increased. Constipation has been then associated with different bacterial patterns in autistic and neurotypical subjects, with constipated autistic individuals characterized by high levels of bacterial taxa belonging to Escherichia/Shigella and Clostridium cluster XVIII. We also observed that the relative abundance of the fungal genus Candida was more than double in the autistic than neurotypical subjects, yet due to a larger dispersion of values, this difference was only partially significant.

conclusionsThe finding that, besides the bacterial gut microbiota, also the gut mycobiota contributes to the alteration of the intestinal microbial community structure in ASDs opens the possibility for new potential intervention strategies aimed at the relief of gastrointestinal symptoms in ASDs.

Indexed as

Gastrointestinal MicrobiomeAdolescentAutism Spectrum DisorderBacillotaBacteriaChildChild, PreschoolClostridiumConstipationFecesFemaleFungiGastrointestinal DiseasesGastrointestinal TractHumansLactobacillusAutism spectrum disordersConstipationGut microbiotaMetataxonomyMycobiota

Identifiers

PMID28222761
PMCPMC5320696
OpenAlexW2589674438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.