ArticleRetrovirology2017
Spatiotemporal dynamics of HIV-1 transmission in France (1999-2014) and impact of targeted prevention strategies.
Article in Retrovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- HIV epidemic and needs beyond fast-track cities: a transmission network analysis to study the dynamics of HIV clusters in a French region near Paris.Microbiology spectrum · 2026Article
- Towards More Accessible and More Inclusive PrEP to Break the Cycle of HIV in France.Journal of the International AIDS Society · 2026Article
- Unraveling HIV-1 spread in Southwest China: a phylogenetic and molecular network approach.Frontiers in microbiology · 2026Article
- Dynamics of clustering rates in the Rhode Island HIV-1 epidemic.AIDS (London, England) · 2025Article
- Benefits of HIV-1 transmission cluster surveillance: a French retrospective observational study of the molecular and epidemiological co-evolution of recent circulating recombinant forms 94 and 132.Journal of the International AIDS Society · 2025Observational
- DNA ultra-sensitive quantification, a technology for studying HIV unintegrated linear DNA.Cell reports methods · 2023Article
- Epidemiological characteristics of HIV transmission in southeastern China from 2015 to 2020 based on HIV molecular network.Frontiers in public health · 2023Article
- Reconstructing the Temporal Origin and the Transmission Dynamics of the HIV Subtype B Epidemic in St. Petersburg, Russia.Viruses · 2022Article
- Transmitted HIV-1 is more virulent in heterosexual individuals than men-who-have-sex-with-men.PLoS pathogens · 2022Article
- Article
- Characterizing genetic transmission networks among newly diagnosed HIV-1 infected individuals in eastern China: 2012-2016.PloS one · 2022Article
- Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013-2020.Viruses · 2021Article
- Priority Intervention Targets Identified Using an In-Depth Sampling HIV Molecular Network in a Non-Subtype B Epidemics Area.Frontiers in cellular and infection microbiology · 2021Article
- Article
- Article
- Increasing prevalence and local transmission of non-B HIV-1 subtypes in the French Antilles and French Guiana between 1995 and 2018.Virus evolution · 2020Article
- Molecular network-based intervention brings us closer to ending the HIV pandemic.Frontiers of medicine · 2020Review
- Dynamics of HIV-1 Molecular Networks Reveal Effective Control of Large Transmission Clusters in an Area Affected by an Epidemic of Multiple HIV Subtypes.Frontiers in microbiology · 2020Article
- Phylogenetic clustering networks among heterosexual migrants with new HIV diagnoses post-migration in Australia.PloS one · 2020Article
- Nation-Wide Viral Sequence Analysis of HIV-1 Subtype B Epidemic in 2003-2012 Revealed a Contribution of Men Who Have Sex With Men to the Transmission Cluster Formation and Growth in Japan.Frontiers in reproductive health · 2020Article
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14 authors.
Funding
Abstract
backgroundCharacterizing HIV-1 transmission networks can be important in understanding the evolutionary patterns and geospatial spread of the epidemic. We reconstructed the broad molecular epidemiology of HIV from individuals with primary HIV-1 infection (PHI) enrolled in France in the ANRS PRIMO C06 cohort over 15 years.
resultsSociodemographic, geographic, clinical, biological and pol sequence data from 1356 patients were collected between 1999 and 2014. Network analysis was performed to infer genetic relationships, i.e. clusters of transmission, between HIV-1 sequences. Bayesian coalescent-based methods were used to examine the temporal and spatial dynamics of identified clusters from different regions in France. We also evaluated the use of network information to target prevention efforts. Participants were mostly Caucasian (85.9%) and men (86.7%) who reported sex with men (MSM, 71.4%). Overall, 387 individuals (28.5%) were involved in clusters: 156 patients (11.5%) in 78 dyads and 231 participants (17%) in 42 larger clusters (median size: 4, range 3-41). Compared to individuals with single PHI (n = 969), those in clusters were more frequently men (95.9 vs 83%, p < 0.01), MSM (85.8 vs 65.6%, p < 0.01) and infected with CRF02_AG (20.4 vs 13.4%, p < 0.01). Reconstruction of viral migrations across time suggests that Paris area was the major hub of dissemination of both subtype B and CRF02_AG epidemics. By targeting clustering individuals belonging to the identified active transmission network before 2010, 60 of the 143 onward transmissions could have been prevented.
conclusionThese analyses support the hypothesis of a recent and rapid rise of CRF02_AG within the French HIV-1 epidemic among MSM. Combined with a short turnaround time for sample processing, targeting prevention efforts based on phylogenetic monitoring may be an efficient way to deliver prevention interventions but would require near real time targeted interventions on the identified index cases and their partners.
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