SynthesisBMC infectious diseases2017
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis.
Synthesis in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04084782 (An Internet Mediated Research Study to Assess the Quality of Life of Consumers With Self-reported Fungal Nail Infection), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Internet Mediated Research Study to Assess the Quality of Life of Consumers With Self-reported Fungal Nail Infection (Onychomycosis) During Treatment With Scholl Fungal Nail.
Who cites it
28 citing papers in PubMed, 84 citations in OpenAlex.
- Artificial Intelligence in the Diagnosis of Superficial Mycoses: A Scoping Review.Journal of fungi (Basel, Switzerland) · 2026Review
- A CRISPR-Cas12a and Quantum-Dot Lateral-Flow Assay for Rapid Species-Level Detection of Trichophyton rubrum.Mycoses · 2026Article
- Artifact-Aware Fungal Detection in Dermatophytosis: A Transformer-Based Approach for KOH Microscopy.Bioengineering (Basel, Switzerland) · 2026Article
- Efficacy of Intralesional Platelet-Rich Plasma in Treatment of Fingernail Onychomycosis: A Randomized Controlled Trial.Dermatology practical & conceptual · 2026Article
- Article
- Diagnostic accuracy of fluorescence microscopy of hematoxylin-eosin-stained nail sections for onychomycosis.Frontiers in medicine · 2026Article
- Comparison of positive detection rates between fluorescent staining and traditional KOH wet mount methods in the diagnosis of superficial fungal skin infections and analysis of factors associated with missed diagnosis.Frontiers in medicine · 2026Article
- Efficacy of Topical Antifungal Nail Solution Versus Topical Placebo Solution for the Treatment of Pedal Onychomycosis: A Randomized Controlled Trial.Infectious diseases and therapy · 2025Article
- Analysis of Causative Factors and Potential Predictors of Onychomycosis: A Retrospective Single-Center Study in Poland.Journal of fungi (Basel, Switzerland) · 2025Article
- Mini review on skin biopsy: traditional and modern techniques.Frontiers in medicine · 2025Review
- [Conventional and molecular diagnostics in onychomycosis-part 2 : Molecular identification of causative dermatophytes by polymerase chain reaction and sequence analysis of the internal transcribed spacer region of ribosomal DNA].Dermatologie (Heidelberg, Germany) · 2024Article
- Low positivity rate and high percentage of nondermatophyte molds in an analysis of 35,257 fungal nail culture results from a United States national commercial laboratory, 2019-2022.JAAD international · 2023Article
- Single-Point Nail Sampling to Diagnose Onychomycosis Caused by Non-Dermatophyte Molds: Utility of Polymerase Chain Reaction (PCR) and Histopathology.Journal of fungi (Basel, Switzerland) · 2023Article
- Evaluation of Thermography as a Diagnostic Technique in Asymptomatic or Incipient Onychomycosis.Journal of fungi (Basel, Switzerland) · 2023Article
- Deep Learning Assisted Diagnosis of Onychomycosis on Whole-Slide Images.Journal of fungi (Basel, Switzerland) · 2022Article
- Diagnosing Onychomycosis: What's New?Journal of fungi (Basel, Switzerland) · 2022Review
- Updated Perspectives on the Diagnosis and Management of Onychomycosis.Clinical, cosmetic and investigational dermatology · 2022Review
- Evaluating Onychomycosis Outcomes 2 Months into an 11-month-long Efinaconazole Regimen: The Role of Optical Coherence Tomography.The Journal of clinical and aesthetic dermatology · 2021Article
- Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions.Scientific reports · 2021Article
- Diagnosis of Onychomycosis: From Conventional Techniques and Dermoscopy to Artificial Intelligence.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOnychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic Acid-Schiff -PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis.
methodsA systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and Epidat using a random effects model.
resultsThe efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies.
conclusionThe diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.