ArticlePharmaceutical biology2017
Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives.Biomolecules · 2019Pooled it
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- Novel Biotinylated Cu(II)-Phenanthroline Complexes: 2D and 3D Cytotoxic Activity and Mechanistic Insight.Molecules (Basel, Switzerland) · 2023Article
- Natural essential oils as a new therapeutic tool in colorectal cancer.Cancer cell international · 2022Review
- A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight.Molecules (Basel, Switzerland) · 2022Review
- Nerolidol, a sesquiterpene, attenuates oxidative stress and inflammation in acetic acid-induced colitis in rats.Molecular and cellular biochemistry · 2021Article
- Review
- Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma.Cancers · 2020Review
- Essential Oil Chemical Variability inPlants (Basel, Switzerland) · 2020Article
- Phytochemical Analysis, Antioxidant, Antibacterial, Cytotoxic, and Enzyme Inhibitory Activities ofFrontiers in pharmacology · 2020Article
- Chemical Characterization and Bioactivity of Extracts fromAntioxidants (Basel, Switzerland) · 2019Article
- Exploring new applications of tulip tree (Liriodendron tulipifera L.): leaf essential oil as apoptotic agent for human glioblastoma.Environmental science and pollution research international · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThymus alternans Klokov (Lamiaceae) is a neglected species of the genus Thymus (Sect. Serpyllum) endemic to Carpathian area, where it is used as a flavouring agent and for medicinal purposes.
objectiveThe aim of the work was to identify antiproliferative constituents from the flowering aerial parts of this plant. MATERIALS AND
methodsThymus alternans extracts were analyzed by HPLC-MS
resultsThe structures of the isolated compounds were achieved on the basis of H-NMR and MS experiments. Luteolin-4'-O-β-d-glucopyranoside (P1), chrysoeriol-7-O-β-d-glucopyranoside (P2), chrysoeriol-5-O-β-d-glucopyranoside (P3), apigenin-7-O-β-d-glucopyranoside (P4), rosmarinic acid (P5), rosmarinic acid-3'-O-β-d-glucopyranoside (P6), caffeic acid-3-O-β-d-glucopyranoside (P7), 3α-hydroxy-urs-12,15-diene (T1), α-amyrin (T2), β-amyrin (T3), isoursenol (T4), epitaraxerol (T5), and oleanolic acid (T6). GC-MS analysis revealed that the EO of T. alternans was devoid of phenols and belonged to the nerolidol-chemotype, that is typical of the Sect. Serpyllum. The six purified triterpenes (T1-T6) were active with IC
conclusionThe reported results suggest that T. alternans can be considered as a good source of phytoconstituents with possible importance in the pharmaceutical field.
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